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A cellular automata model of enzyme kinetics

Kier, Lemont B.
Cheng, Chao-Kun
Testa, Bernard
Published in Pharmaceutical Research. 1996, vol. 14, no. 4, p. 227-231, 226
Abstract We have developed a cellular automata model of an enzyme reaction with a substrate in water. The model produces Michaelis-Menten kinetics with good Lineweaver-Burk plots. The variation in affinity parameters predicts that, in general, hydrophobic substrates are more reactive with enzymes, this attribute being more important than the relationship between enzyme and substrate. The ease of generation and the illustrative value of the model lead us to believe that cellular automata models have a useful role in the study of dynamic phenomena such as enzyme kinetics.
Keywords AutomationComputer SimulationEnzymes/*metabolismKineticsModels, Chemical
PMID: 9076636
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KIER, Lemont B. et al. A cellular automata model of enzyme kinetics. In: Pharmaceutical Research, 1996, vol. 14, n° 4, p. 227-231, 226.

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Deposited on : 2010-08-06

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