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Scientific article
English

Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR

Published inHelvetica chimica acta, vol. 84, no. 3, p. 552-570
Publication date2001
Abstract

Fifty-nine xanthones (= 9H-xanthen-9-ones) of natural or synthetic origin were investigated for their inhibitory activity toward monoamine-oxidase A (MAO-A) and MAO-B. The compounds demonstrated reversible. time-independent activities, with selectivity toward MAO-A. The most active inhibitor had an IC50 of 40 nM. Electron absorption spectroscopy revealed the formation of a 1:1 charge-transfer complex between lumiflavine and xanthones. 3D-QSAR Studies according to the CoMFA/GOLPE procedure provided information on the relationship between steric and electrostatic fields and MAO-A inhibition. The ALMOND procedure yielded additional topographical information on structural factors favoring activity

Affiliation Not a UNIGE publication
Citation (ISO format)
GNERRE, Carmela et al. Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR. In: Helvetica chimica acta, 2001, vol. 84, n° 3, p. 552–570.
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  • PID : unige:10582
ISSN of the journal0018-019X
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