Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR

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Title		Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR
Authors		Gnerre, Carmela Thull, Ulrike Gaillard, Patrick Carrupt, Pierre-Alain Testa, Bernard Fernandes, Eduarda Silva, Francisco Pinto, Manuela Pinto, Madalena M. M. Wolfender, Jean-Luc Hostettmann, Kurt Cruciani, Gabriele show all authors [1 - 12]
Published in		Helvetica chimica acta. 2001, vol. 84, no. 3, p. 552-570
Abstract		Fifty-nine xanthones (= 9H-xanthen-9-ones) of natural or synthetic origin were investigated for their inhibitory activity toward monoamine-oxidase A (MAO-A) and MAO-B. The compounds demonstrated reversible. time-independent activities, with selectivity toward MAO-A. The most active inhibitor had an IC50 of 40 nM. Electron absorption spectroscopy revealed the formation of a 1:1 charge-transfer complex between lumiflavine and xanthones. 3D-QSAR Studies according to the CoMFA/GOLPE procedure provided information on the relationship between steric and electrostatic fields and MAO-A inhibition. The ALMOND procedure yielded additional topographical information on structural factors favoring activity
Full text		Article - Limited access to UNIGE
Citation (ISO format)		GNERRE, Carmela et al. Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR. In: Helvetica chimica acta, 2001, vol. 84, n° 3, p. 552-570. https://archive-ouverte.unige.ch/unige:10582