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Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR |
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Published in | Helvetica chimica acta. 2001, vol. 84, no. 3, p. 552-570 | |
Abstract | Fifty-nine xanthones (= 9H-xanthen-9-ones) of natural or synthetic origin were investigated for their inhibitory activity toward monoamine-oxidase A (MAO-A) and MAO-B. The compounds demonstrated reversible. time-independent activities, with selectivity toward MAO-A. The most active inhibitor had an IC50 of 40 nM. Electron absorption spectroscopy revealed the formation of a 1:1 charge-transfer complex between lumiflavine and xanthones. 3D-QSAR Studies according to the CoMFA/GOLPE procedure provided information on the relationship between steric and electrostatic fields and MAO-A inhibition. The ALMOND procedure yielded additional topographical information on structural factors favoring activity | |
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Citation (ISO format) | GNERRE, Carmela et al. Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR. In: Helvetica chimica acta, 2001, vol. 84, n° 3, p. 552-570. https://archive-ouverte.unige.ch/unige:10582 |