Scientific Article
previous document  unige:10582  next document
add to browser collection

Natural and synthetic xanthones as monoamine oxidase inhibitors: Biological assay and 3D-QSAR

Gnerre, Carmela
Thull, Ulrike
Gaillard, Patrick
Testa, Bernard
Fernandes, Eduarda
Silva, Francisco
Pinto, Manuela
show hidden authors show all authors [1 - 12]
Published in Helvetica Chimica Acta. 2001, vol. 84, no. 3, p. 552-570
Abstract Fifty-nine xanthones (= 9H-xanthen-9-ones) of natural or synthetic origin were investigated for their inhibitory activity toward monoamine-oxidase A (MAO-A) and MAO-B. The compounds demonstrated reversible. time-independent activities, with selectivity toward MAO-A. The most active inhibitor had an IC50 of 40 nM. Electron absorption spectroscopy revealed the formation of a 1:1 charge-transfer complex between lumiflavine and xanthones. 3D-QSAR Studies according to the CoMFA/GOLPE procedure provided information on the relationship between steric and electrostatic fields and MAO-A inhibition. The ALMOND procedure yielded additional topographical information on structural factors favoring activity
Stable URL
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE

194 hits

0 download


Deposited on : 2010-08-06

Export document
Format :
Citation style :