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Scientific Article
unige:10575 
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Mechanisms of liposomes/water partitioning of (p-methylbenzyl)alkylamines |
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| Authors | ||
| Published in | Pharmaceutical research. 1998, vol. 15, no. 9, p. 1407-1413 | |
| Abstract | PURPOSE: The objective of this study was to compare and interpret the variations in lipophilicity of homologous (p-methylbenzyl)alkylamines (MBAAs) in isotropic (octanol/water) and anisotropic (zwitterionic liposomes/water) system. METHODS: Two experimental approaches were used, namely the pH-metric method to measure lipophilicity parameters in octanol/water and liposomes/water systems, and changes in NMR relaxation rates to validate the former method and to gain additional insights into the mechanisms of liposomes/water partitioning. RESULTS: For long-chain homologues (N-butyl to N-heptyl), the octanol/water and liposomes/water systems mostly expressed hydrophobicity. In contrast, the lipophilicity of the shorter homologues (N-methyl to N-propyl) in the two systems expressed various electrostatic and polar interactions. CONCLUSIONS: The study sheds light on the molecular interactions between zwitterionic liposomes and amphiphilic solutes in neutral and cationic form. | |
| Keywords | Alkanes/*chemistry — Drug Carriers — Lipids/chemistry — Liposomes/chemistry — Magnetic Resonance Spectroscopy — Water/*chemistry | |
| Identifiers | PMID: 9755893 | |
| Full text |
Article - Limited access to UNIGE Other version: http://www.springerlink.com/content/n7281xp6234q444x/fulltext.pdf |
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| Citation (ISO format) | FRUTTERO, Roberta et al. Mechanisms of liposomes/water partitioning of (p-methylbenzyl)alkylamines. In: Pharmaceutical research, 1998, vol. 15, n° 9, p. 1407-1413. https://archive-ouverte.unige.ch/unige:10575 |
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