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Scientific article
English

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase

Published inJournal of medicinal chemistry, vol. 44, no. 19, p. 3195-3198
Publication date2001
Abstract

A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3-100 microM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease beta-amyloid deposition.

Keywords
  • Acetylcholinesterase/chemistry
  • Animals
  • Cholinesterase Inhibitors/*chemical synthesis/chemistry
  • Coumarins/*chemical synthesis/chemistry
  • Eels
  • Monoamine Oxidase Inhibitors/*chemical synthesis/chemistry
  • Structure-Activity Relationship
Affiliation Not a UNIGE publication
Citation (ISO format)
BRUHLMANN, C. et al. Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. In: Journal of medicinal chemistry, 2001, vol. 44, n° 19, p. 3195–3198. doi: 10.1021/jm010894d
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ISSN of the journal0022-2623
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