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Titles listCoumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase
Titles listCoumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase
Scientific Article
unige:10543 
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Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase |
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| Authors | ||
| Published in | Journal of medicinal chemistry. 2001, vol. 44, no. 19, p. 3195-3198 | |
| Abstract | A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3-100 microM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease beta-amyloid deposition. | |
| Keywords | Acetylcholinesterase/chemistry — Animals — Cholinesterase Inhibitors/*chemical synthesis/chemistry — Coumarins/*chemical synthesis/chemistry — Eels — Monoamine Oxidase Inhibitors/*chemical synthesis/chemistry — Structure-Activity Relationship | |
| Identifiers | DOI: 10.1021/jm010894d PMID: 11543689 | |
| Full text | ||
| Citation (ISO format) | BRUHLMANN, C. et al. Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. In: Journal of medicinal chemistry, 2001, vol. 44, n° 19, p. 3195-3198. doi: 10.1021/jm010894d https://archive-ouverte.unige.ch/unige:10543 |
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