Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes

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Title		Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes
Authors		Bouchard, Géraldine Galland, Alexandra Carrupt, Pierre-Alain Gulaboski, R. Mirceski, V. Scholz, F. Girault, H. H.
Published in		Physical Chemistry Chemical Physics. 2003, vol. 5, no. 17, p. 3748-3751
Abstract		The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability of this electrochemical system to give reliable values of lipophilicity for organic ions, as well as to gain more information on the lipophilic behaviour of anions in the n-octanol/water system. Results were used to clarify the solvation mechanisms responsible for ion partitioning and to compare the information obtained in the two solvent systems n-octanol/water and 1,2-dichloroethane/water
Identifiers		DOI: 10.1039/b304113a
Full text		Article - Limited access to UNIGE Other version: http://www.rsc.org/ej/CP/2003/b304113a.pdf
Citation (ISO format)		BOUCHARD, Géraldine et al. Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes. In: Physical Chemistry Chemical Physics, 2003, vol. 5, n° 17, p. 3748-3751. https://archive-ouverte.unige.ch/unige:10542