UNIGE document Scientific Article
previous document  unige:105281  next document
add to browser collection
Title

Activities of an intravenous formulation of itraconazole in experimental disseminated aspergillus, candida, and cryptococcus infections

Authors
Odds, F. C.
Van Dorsselaer, P.
Van Gerven, F.
Published in Antimicrobial Agents and Chemotherapy. 2000, vol. 44, no. 11, p. 3180-3183
Abstract An intravenous (i.v.) formulation of itraconazole was evaluated in disseminated fungal infection models in guinea pigs. In acute disseminated Candida albicans and Aspergillus fumigatus infections, treatment at 5 mg/kg of body weight twice a day (b.i.d.) significantly prolonged survival. In these models and in animals with chronic disseminated cryptococcosis, itraconazole given i.v. at 2.5 and 5 mg/kg b.i.d. greatly reduced the proportions of organs with culture-detectable fungal burdens. The efficacy of i.v. itraconazole in these animal models justifies its further investigation for the treatment of life-threatening mycoses in humans.
Identifiers
Full text
Structures
Citation
(ISO format)
ODDS, F. C. et al. Activities of an intravenous formulation of itraconazole in experimental disseminated aspergillus, candida, and cryptococcus infections. In: Antimicrobial Agents and Chemotherapy, 2000, vol. 44, n° 11, p. 3180-3183. https://archive-ouverte.unige.ch/unige:105281

34 hits

0 download

Update

Deposited on : 2018-06-08

Export document
Format :
Citation style :