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Title

Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production

Authors
Tubbs, Emily
Axelsson, Annika S
Vial, Guillaume
Rieusset, Jennifer
Rosengren, Anders H
Published in Molecular and Cellular Endocrinology. 2018, vol. 461, p. 205-214
Abstract Exaggerated hepatic glucose production is one of the hallmarks of type 2 diabetes. Sulforaphane (SFN) has been suggested as a new potential anti-diabetic compound. However, the effects of SFN in hepatocytes are yet unclear. Accumulating evidence points to the close structural contacts between the ER and mitochondria, known as mitochondria-associated ER membranes (MAMs), as important hubs for hepatic metabolism. We wanted to investigate whether SFN could affect hepatic glucose production and MAMs.
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PMID: 28923347
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TUBBS, Emily et al. Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production. In: Molecular and Cellular Endocrinology, 2018, vol. 461, p. 205-214. https://archive-ouverte.unige.ch/unige:104787

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Deposited on : 2018-05-31

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