

Other version: http://www.nature.com/ng/journal/v34/n3/pdf/ng1174.pdf
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Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep |
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Authors | ||
Published in | Nature genetics. 2003, vol. 34, no. 3, p. 320-325 | |
Abstract | In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates overexpression of Glo1 (encoding glyoxylase 1), a gene involved in the detoxification of metabolic by-products. Administration of acetyl-L-carnitine (ALCAR) to mutant mice significantly recovers slow theta and Glo1 overexpression. Thus, an underappreciated metabolic pathway involving fatty acid beta-oxidation also regulates theta oscillations during sleep. | |
Keywords | Acetylcarnitine/administration & dosage — Acyl-CoA Dehydrogenase — Animals — Brain/ enzymology — Disease Models, Animal — Electroencephalography — Fatty Acid Desaturases/ deficiency/genetics/metabolism — Fatty Acids/ metabolism — Immunoblotting — Immunoenzyme Techniques — In Situ Hybridization — Lactoylglutathione Lyase/metabolism — Liver/enzymology — Male — Mice — Mice, Inbred AKR — Mice, Inbred BALB C — Mice, Inbred C57BL — Molecular Sequence Data — Nootropic Agents/administration & dosage — Oligonucleotide Array Sequence Analysis — Oxidation-Reduction — Sleep, REM/drug effects — Theta Rhythm | |
Identifiers | DOI: 10.1038/ng1174 PMID: 12796782 | |
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![]() ![]() Other version: http://www.nature.com/ng/journal/v34/n3/pdf/ng1174.pdf |
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Structures | ||
Research group | Progéniteurs neuronaux | |
Citation (ISO format) | TAFTI, Mehdi et al. Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. In: Nature genetics, 2003, vol. 34, n° 3, p. 320-325. doi: 10.1038/ng1174 https://archive-ouverte.unige.ch/unige:10455 |