Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep

Tafti, Mehdi; Petit, Brice; Chollet, Didier; Neidhart, Elisabeth; De Bilbao, Fabienne; Kiss, Jozsef Zoltan; Wood, P. A.; Franken, Paul

doi:10.1038/ng1174

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Title		Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep
Authors		Tafti, Mehdi Petit, Brice Chollet, Didier Neidhart, Elisabeth De Bilbao, Fabienne Kiss, Jozsef Zoltan Wood, P. A. Franken, Paul
Published in		Nature Genetics. 2003, vol. 34, no. 3, p. 320-325
Abstract		In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates overexpression of Glo1 (encoding glyoxylase 1), a gene involved in the detoxification of metabolic by-products. Administration of acetyl-L-carnitine (ALCAR) to mutant mice significantly recovers slow theta and Glo1 overexpression. Thus, an underappreciated metabolic pathway involving fatty acid beta-oxidation also regulates theta oscillations during sleep.
Keywords		Acetylcarnitine/administration & dosage — Acyl-CoA Dehydrogenase — Animals — Brain/ enzymology — Disease Models, Animal — Electroencephalography — Fatty Acid Desaturases/ deficiency/genetics/metabolism — Fatty Acids/ metabolism — Immunoblotting — Immunoenzyme Techniques — In Situ Hybridization — Lactoylglutathione Lyase/metabolism — Liver/enzymology — Male — Mice — Mice, Inbred AKR — Mice, Inbred BALB C — Mice, Inbred C57BL — Molecular Sequence Data — Nootropic Agents/administration & dosage — Oligonucleotide Array Sequence Analysis — Oxidation-Reduction — Sleep, REM/drug effects — Theta Rhythm
Identifiers		DOI: 10.1038/ng1174 PMID: 12796782
Full text		Article - Limited access to UNIGE Other version: http://www.nature.com/ng/journal/v34/n3/pdf/ng1174.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Research group		Progéniteurs neuronaux
Citation (ISO format)		TAFTI, Mehdi et al. Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. In: Nature Genetics, 2003, vol. 34, n° 3, p. 320-325. doi: 10.1038/ng1174 https://archive-ouverte.unige.ch/unige:10455