UNIGE document Scientific Article
previous document  unige:103226  next document
add to browser collection

TOR Complexes and the Maintenance of Cellular Homeostasis

Published in Trends in cell biology. 2016, vol. 26, no. 2, p. 148-159
Abstract The Target of Rapamycin (TOR) is a conserved serine/threonine (ser/thr) kinase that functions in two, distinct, multiprotein complexes called TORC1 and TORC2. Each complex regulates different aspects of eukaryote growth: TORC1 regulates cell volume and/or mass by influencing protein synthesis and turnover, while TORC2, as detailed in this review, regulates cell surface area by influencing lipid production and intracellular turgor. TOR complexes function in feedback loops, implying that downstream effectors are also likely to be involved in upstream regulation. In this regard, the notion that TORCs function primarily as mediators of cellular and organismal homeostasis is fundamentally different from the current, predominate view of TOR as a direct transducer of extracellular biotic and abiotic signals.
Keywords Cell Physiological PhenomenaCell SizeHomeostasis/geneticsHumansLipid Metabolism/physiologyMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Multiprotein Complexes/physiologyTOR Serine-Threonine Kinases/physiologyYeasts
PMID: 26546292
Full text
Article (Published version) (1.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Loewith
(ISO format)
ELTSCHINGER, Sandra, LOEWITH, Robbie Joséph. TOR Complexes and the Maintenance of Cellular Homeostasis. In: Trends in Cell Biology, 2016, vol. 26, n° 2, p. 148-159. doi: 10.1016/j.tcb.2015.10.003 https://archive-ouverte.unige.ch/unige:103226

364 hits

0 download


Deposited on : 2018-03-27

Export document
Format :
Citation style :