Dual action antifungal small molecule modulates multidrug efflux and TOR signaling
ContributorsShekhar-Guturja, Tanvi; Gunaherath, G M Kamal B; Wijeratne, E M Kithsiri; Lambert, Jean-Philippe; Averette, Anna F; Lee, Soo Chan; Kim, Taeyup; Bahn, Yong-Sun; Tripodi, Farida; Ammar, Ron; Döhl, Katja; Niewola-Staszkowska, Karolina; Schmitt, Lutz; Loewith, Robbie Joséph; Roth, Frederick P; Sanglard, Dominique; Andes, David; Nislow, Corey; Coccetti, Paola; Gingras, Anne-Claude; Heitman, Joseph; Gunatilaka, A A Leslie; Cowen, Leah E
Published inNature chemical biology, vol. 12, no. 10, p. 867-875
Publication date2016
Abstract
Keywords
- ATP-Binding Cassette Transporters/genetics/metabolism
- Antifungal Agents/chemistry/pharmacology
- Depsipeptides/chemical synthesis/chemistry/pharmacology
- Drug Resistance
- Fungal/drug effects
- Drug Resistance
- Multiple/drug effects
- Fungi/drug effects/metabolism
- HSP90 Heat-Shock Proteins/antagonists & inhibitors/metabolism
- Microbial Sensitivity Tests
- Mycoses/drug therapy/microbiology
- Protein Kinase Inhibitors/chemical synthesis/chemistry/pharmacology
- Saccharomyces cerevisiae Proteins/genetics/metabolism
- Signal Transduction/drug effects
- Small Molecule Libraries/chemistry/pharmacology
- TOR Serine-Threonine Kinases/antagonists & inhibitors/metabolism
Research groups
Citation (ISO format)
SHEKHAR-GUTURJA, Tanvi et al. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. In: Nature chemical biology, 2016, vol. 12, n° 10, p. 867–875. doi: 10.1038/nchembio.2165
Main files (1)
Article (Published version)
Identifiers
- PID : unige:103221
- DOI : 10.1038/nchembio.2165
- PMID : 27571477
Additional URL for this publicationhttps://www.nature.com/articles/nchembio.2165
Journal ISSN1552-4469