Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases

Mukherjee, Budhaditya; Tessaro, Francesca; Vahokoski, Juha; Kursula, Inari; Marq, Jean-Baptiste; Scapozza, Leonardo; Soldati-Favre, Dominique

doi:10.15252/embj.201798047

Scientific article

English

Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases

ContributorsMukherjee, Budhaditya; Tessaro, Francesca; Vahokoski, Juha; Kursula, Inari; Marq, Jean-Baptiste; Scapozza, Leonardo; Soldati-Favre, Dominique

Published inEMBO Journal, e98047

Publication date2018

Affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques
Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

Research groups

Biologie d'un parasite intracellulaire obligatoire (773)

Funding

Autre - Carigest
Swiss National Science Foundation - Non-Haemoglobin Degrading Plasmepsins: Drug Targets validation from Bench to Field [156825]
Swiss National Science Foundation - FN3100A0-116722 and IZLIZ3- 156825

Citation (ISO format)

MUKHERJEE, Budhaditya et al. Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases. In: EMBO Journal, 2018, p. e98047. doi: 10.15252/embj.201798047

Article (Published version)

Identifiers

PID : unige:103072
DOI : 10.15252/embj.201798047
PMID : 29519896

Journal ISSN0261-4189

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Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases

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