UNIGE document Scientific Article
previous document  unige:102913  next document
add to browser collection

The HLA-B landscape of Africa: Signatures of pathogen-driven selection and molecular identification of candidate alleles to malaria protection

Černý, Viktor
show hidden authors show all authors [1 - 14]
Published in Molecular ecology. 2017, vol. 26, no. 22, p. 6238-6252
Abstract Human leukocyte antigen (HLA) genes play a key role in the immune response to infectious diseases, some of which are highly prevalent in specific environments, like malaria in sub-Saharan Africa. Former case-control studies showed that one particular HLA-B allele, B*53, was associated with malaria protection in Gambia, but this hypothesis was not tested so far within a population genetics framework. In this study, our objective was to assess whether pathogen-driven selection associated with malaria contributed to shape the HLA-B genetic landscape of Africa. To that aim, we first typed the HLA-A and -B loci in 484 individuals from 11 populations living in different environments across the Sahel, and we analysed these data together with those available for 29 other populations using several approaches including linear modelling on various genetic, geographic and environmental parameters. In addition to relevant signatures of populations' demography and migrations history in the genetic differentiation patterns of both HLA-A and -B loci, we found that the frequencies of three HLA alleles, B*53, B*78 and A*74, were significantly associated with Plasmodium falciparum malaria prevalence, suggesting their increase through pathogen-driven selection in malaria-endemic environments. The two HLA-B alleles were further identified, by high-throughput sequencing, as B*53:01:01 (in putative linkage disequilibrium with one HLA-C allele, C*04:01:01:01) and B*78:01 in all but one individuals tested, making them appropriate candidates to malaria protection. These results highlight the role of environmental factors in the evolution of the HLA polymorphism and open key perspectives for functional studies focusing on HLA peptide-binding properties.
Keywords Africa South of the SaharaAllelesDisease Resistance/geneticsGeneticsPopulationHLA-B Antigens/geneticsHumansLinkage DisequilibriumMalariaFalciparum/genetics
PMID: 28950417
Full text
Article (Published version) (999 Kb) - public document Free access
Research groups Groupe Sanchez-Mazas
Transplantation immunologie et osteoimmunologie (561)
Unité d'anthropologie
Swiss National Science Foundation: 31003A_144180
(ISO format)
SANCHEZ-MAZAS, Alicia et al. The HLA-B landscape of Africa: Signatures of pathogen-driven selection and molecular identification of candidate alleles to malaria protection. In: Molecular Ecology, 2017, vol. 26, n° 22, p. 6238-6252. doi: 10.1111/mec.14366 https://archive-ouverte.unige.ch/unige:102913

442 hits



Deposited on : 2018-03-13

Export document
Format :
Citation style :