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Quantifying indices of short- and long-range white matter connectivity at each cortical vertex

Zöller, Daniela
Published in PloS one. 2017, vol. 12, no. 11, e0187493
Abstract Several neurodevelopmental diseases are characterized by impairments in cortical morphology along with altered white matter connectivity. However, the relationship between these two measures is not yet clear. In this study, we propose a novel methodology to compute and display metrics of white matter connectivity at each cortical point. After co-registering the extremities of the tractography streamlines with the cortical surface, we computed two measures of connectivity at each cortical vertex: the mean tracts' length, and the proportion of short- and long-range connections. The proposed measures were tested in a clinical sample of 62 patients with 22q11.2 deletion syndrome (22q11DS) and 57 typically developing individuals. Using these novel measures, we achieved a fine-grained visualization of the white matter connectivity patterns at each vertex of the cortical surface. We observed an intriguing pattern of both increased and decreased short- and long-range connectivity in 22q11DS, that provides novel information about the nature and topology of white matter alterations in the syndrome. We argue that the method presented in this study opens avenues for additional analyses of the relationship between cortical properties and patterns of underlying structural connectivity, which will help clarifying the intrinsic mechanisms that lead to altered brain structure in neurodevelopmental disorders.
Keywords AdolescentAdultBrain Mapping/methodsCase-Control StudiesCerebral Cortex/diagnostic imaging/physiopathologyChildDiGeorge Syndrome/diagnostic imaging/physiopathologyDiffusion Tensor Imaging/methodsFemaleHumansMaleWhite Matter/diagnostic imaging/physiopathologyYoung Adult
PMID: 29141024
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Research groups Autism Brain and Behavior Lab (1033)
Laboratoire d'imagerie et de psychopathologie développementale (693)
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PADULA, Maria et al. Quantifying indices of short- and long-range white matter connectivity at each cortical vertex. In: PLOS ONE, 2017, vol. 12, n° 11, p. e0187493. doi: 10.1371/journal.pone.0187493 https://archive-ouverte.unige.ch/unige:102776

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Deposited on : 2018-03-07

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