Quantifying indices of short- and long-range white matter connectivity at each cortical vertex

Article Article scientifique Article Quantifying indices of short- and long-range white matter connectivity at each cortical vertex eng 2017 author Padula Maria 811907 author Schaer Marie 0000-0001-8479-6365 510515 author Scariati Jaussi Elisa 594796 author Mutlu Aytac Kadir 767277 author Zöller Daniela author Schneider Maude 594384 author Eliez Stéphan 39336 e0187493 10.1371/journal.pone.0187493 29141024 1932-6203 Several neurodevelopmental diseases are characterized by impairments in cortical morphology along with altered white matter connectivity. However, the relationship between these two measures is not yet clear. In this study, we propose a novel methodology to compute and display metrics of white matter connectivity at each cortical point. After co-registering the extremities of the tractography streamlines with the cortical surface, we computed two measures of connectivity at each cortical vertex: the mean tracts' length, and the proportion of short- and long-range connections. The proposed measures were tested in a clinical sample of 62 patients with 22q11.2 deletion syndrome (22q11DS) and 57 typically developing individuals. Using these novel measures, we achieved a fine-grained visualization of the white matter connectivity patterns at each vertex of the cortical surface. We observed an intriguing pattern of both increased and decreased short- and long-range connectivity in 22q11DS, that provides novel information about the nature and topology of white matter alterations in the syndrome. We argue that the method presented in this study opens avenues for additional analyses of the relationship between cortical properties and patterns of underlying structural connectivity, which will help clarifying the intrinsic mechanisms that lead to altered brain structure in neurodevelopmental disorders. Adolescent Adult Brain Mapping/methods Case-Control Studies Cerebral Cortex/diagnostic imaging/physiopathology Child DiGeorge Syndrome/diagnostic imaging/physiopathology Diffusion Tensor Imaging/methods Female Humans Male White Matter/diagnostic imaging/physiopathology Young Adult Dewey 576.5 Dewey 616.89 135 Département de médecine génétique et développement 21D 60 Département de psychiatrie 225 false 1360 Autism Brain and Behavior Lab 1033 421 Laboratoire d'imagerie et de psychopathologie développementale 693 PLOS ONE 12 11 7866c051-b19a-4fe5-9ee8-7d61bd257681 Article (Published version) Public Quantifying.pdf 9995764 application/pdf CC BY openAccess Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine clinique / Département de psychiatrie

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Quantifying indices of short- and long-range white matter connectivity at each cortical vertex	PLOS ONE			2017	591	216

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Mutlu, Aytac Kadir