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Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels

Liu, J. H.
Espinos, E.
Mordasini, D.
Published in The Journal of Cell Biology. 2001, vol. 153, no. 4, p. 677-686
Abstract Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-a-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through alpha1H T channels.
Keywords Antisense Elements (Genetics)ChildChild, PreschoolHumansInfantMembrane Fusion/physiologyMembrane Potentials/physiologyMuscle Fibers, Skeletal/ cytologyMuscle, Skeletal/ cytology/physiologyPatch-Clamp TechniquesPotassium/metabolismPotassium Channels/ genetics/ metabolismPotassium Channels, Inwardly RectifyingRibonucleases
Stable URL http://archive-ouverte.unige.ch/unige:10272
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PMID: 11352930

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Deposited on : 2010-08-06

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