Scientific article

Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels

Published inThe Journal of cell biology, vol. 153, no. 4, p. 677-686
Publication date2001

Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-a-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through alpha1H T channels.

  • Antisense Elements (Genetics)
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Membrane Fusion/physiology
  • Membrane Potentials/physiology
  • Muscle Fibers, Skeletal/ cytology
  • Muscle, Skeletal/ cytology/physiology
  • Patch-Clamp Techniques
  • Potassium/metabolism
  • Potassium Channels/ genetics/ metabolism
  • Potassium Channels, Inwardly Rectifying
  • Ribonucleases
Citation (ISO format)
FISCHER-LOUGHEED, Jacqueline et al. Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels. In: The Journal of cell biology, 2001, vol. 153, n° 4, p. 677–686.
Updates (1)
ISSN of the journal0021-9525

Technical informations

Creation08/06/2010 1:46:32 PM
First validation08/06/2010 1:46:32 PM
Update time03/14/2023 3:58:27 PM
Status update03/14/2023 3:58:27 PM
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