Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels

Fischer-Lougheed, Jacqueline; Liu, J. H.; Espinos, E.; Mordasini, D.; Bader, Charles; Belin, Dominique; Bernheim, Laurent

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Title		Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels
Authors		Fischer-Lougheed, Jacqueline Liu, J. H. Espinos, E. Mordasini, D. Bader, Charles Belin, Dominique Bernheim, Laurent
Published in		The Journal of Cell Biology. 2001, vol. 153, no. 4, p. 677-686
Abstract		Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-a-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through alpha1H T channels.
Keywords		Antisense Elements (Genetics) — Child — Child, Preschool — Humans — Infant — Membrane Fusion/physiology — Membrane Potentials/physiology — Muscle Fibers, Skeletal/ cytology — Muscle, Skeletal/ cytology/physiology — Patch-Clamp Techniques — Potassium/metabolism — Potassium Channels/ genetics/ metabolism — Potassium Channels, Inwardly Rectifying — Ribonucleases
Identifiers		PMID: 11352930
Full text		Article - Limited access to UNIGE Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192379/pdf/0102021.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation (ISO format)		FISCHER-LOUGHEED, Jacqueline et al. Human myoblast fusion requires expression of functional inward rectifier Kir2.1 channels. In: The Journal of Cell Biology, 2001, vol. 153, n° 4, p. 677-686. https://archive-ouverte.unige.ch/unige:10272