Tolerance and safety of nifurtimox in patients with chronic chagas disease

Jackson, Yves-Laurent Julien; Alirol, Emilie; Getaz, Laurent; Wolff, Hans; Combescure, Christophe; Chappuis, François

doi:10.1086/656917

Scientific article

English

Tolerance and safety of nifurtimox in patients with chronic chagas disease

ContributorsJackson, Yves-Laurent Julien; Alirol, Emilie; Getaz, Laurent; Wolff, Hans; Combescure, Christophe

; Chappuis, François

Published inClinical Infectious Diseases, vol. 51, no. 10, p. e69-75

Publication date2010

Abstract

Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance and safety data in adults are scarce. We aimed to evaluate nifurtimox tolerance and safety in a cohort of Trypanosoma cruzi-infected adult patients in a country of nonendemicity.

Keywords

Adolescent
Adult
Aged
Chagas Disease/drug therapy
Chronic Disease
Female
Humans
Kaplan-Meier Estimate
Latin America/ethnology
Longitudinal Studies
Male
Medication Adherence
Middle Aged
Nifurtimox/adverse effects/therapeutic use
Switzerland
Trypanocidal Agents/adverse effects/therapeutic use

Affiliation

Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires

Research group

Epidémiologie clinique (115)

Citation (ISO format)

JACKSON, Yves-Laurent Julien et al. Tolerance and safety of nifurtimox in patients with chronic chagas disease. In: Clinical Infectious Diseases, 2010, vol. 51, n° 10, p. e69–75. doi: 10.1086/656917

Article (Published version)

Identifiers

PID : unige:102456
DOI : 10.1086/656917
PMID : 20932171

ISSN of the journal1058-4838

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Tolerance and safety of nifurtimox in patients with chronic chagas disease

Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance and safety data in adults are scarce. We aimed to evaluate nifurtimox tolerance and safety in a cohort of Trypanosoma cruzi-infected adult patients in a country of nonendemicity.

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