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Synthesis of deoxyelephantopin analogues

Published in Journal of Antibiotics. 2018, vol. 71, no. 2, p. 248-256
Abstract Deoxyelephantopin is a sesquiterpene lactone that was reported to be as effective in the treatment of mammary tumours and lung metastasis as taxol based on a murine orthotopic cancer model. Its germacrene skeleton harbours three Michael acceptors that can potentially engage a target covalently. Its strained 10-membered ring is densely functionalised and represents an important synthetic challenge. We herein describe our studies towards deoxyelephantopins using a ring-closing metathesis approach and report some unexpected observations.
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Research group Groupe Winssinger
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LAGOUTTE, Roman, SERBA, Christelle, WINSSINGER, Nicolas. Synthesis of deoxyelephantopin analogues. In: Journal of Antibiotics, 2018, vol. 71, n° 2, p. 248-256. doi: 10.1038/ja.2017.132 https://archive-ouverte.unige.ch/unige:101832

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Deposited on : 2018-01-31

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