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Title

Effects of the gut-liver axis on ischemia-mediated hepatocellular carcinoma recurrence in the mouse liver

Authors
Rossetti, Carlo
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Published in Journal of Hepatology. 2018
Abstract There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence, but the involved mechanisms are unclear. Here, we tested the hypothesis that mesenteric congestion due to portal blood flow interruption induces endotoxin-mediated Toll-Like Receptor 4 (Tlr4) engagement, resulting in elevated liver cancer burden. We also assessed the role of remote ischemic preconditioning (RIPC) in this context.
Identifiers
PMID: 29331341
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Article (Accepted version) (3.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Métastases du foie (657)
Transplantation et hépatologie (905)
Citation
(ISO format)
ORCI, Lorenzo et al. Effects of the gut-liver axis on ischemia-mediated hepatocellular carcinoma recurrence in the mouse liver. In: Journal of Hepatology, 2018. doi: 10.1016/j.jhep.2017.12.025 https://archive-ouverte.unige.ch/unige:101476

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Deposited on : 2018-01-18

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