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Effects of the gut-liver axis on ischemia-mediated hepatocellular carcinoma recurrence in the mouse liver

Date de publication2018
Résumé

There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence, but the involved mechanisms are unclear. Here, we tested the hypothesis that mesenteric congestion due to portal blood flow interruption induces endotoxin-mediated Toll-Like Receptor 4 (Tlr4) engagement, resulting in elevated liver cancer burden. We also assessed the role of remote ischemic preconditioning (RIPC) in this context.

Citation (format ISO)
ORCI, Lorenzo et al. Effects of the gut-liver axis on ischemia-mediated hepatocellular carcinoma recurrence in the mouse liver. In: Journal of Hepatology, 2018. doi: 10.1016/j.jhep.2017.12.025
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Article (Accepted version)
accessLevelRestricted
Identifiants
ISSN du journal0168-8278
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Informations techniques

Création18.01.2018 16:05:00
Première validation18.01.2018 16:05:00
Heure de mise à jour15.03.2023 07:45:51
Changement de statut15.03.2023 07:45:51
Dernière indexation17.01.2024 02:04:34
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