Immune Checkpoint Inhibitor-Associated Myocarditis: A New Challenge for Cardiologists

Frigeri, Mauro; Meyer, Philippe; Banfi, Carlo; Giraud, Raphaël; Hachulla-Lemaire, Anne-Lise; Spoerl, David; Friedlaender, Alex; Pugliesi - Rinaldi, Angela; Dietrich, Pierre-Yves

doi:10.1016/j.cjca.2017.09.025

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Title		Immune Checkpoint Inhibitor-Associated Myocarditis: A New Challenge for Cardiologists
Authors		Frigeri, Mauro Meyer, Philippe Banfi, Carlo Giraud, Raphaël Hachulla-Lemaire, Anne-Lise Spoerl, David Friedlaender, Alex Pugliesi - Rinaldi, Angela Dietrich, Pierre-Yves show all authors [1 - 9]
Published in		Canadian Journal of Cardiology. 2018, vol. 34, no. 1, p. 92.e1-92.e3
Abstract		The ever-increasing use of immune checkpoint inhibitors in cancer is leading to a high incidence of autoimmune side effects. This report discusses an autoimmune fulminant myocarditis in an elderly patient with metastatic pulmonary adenocarcinoma in whom the most advanced invasive heart failure therapies were used successfully. She was treated with nivolumab. This case illustrates a severe cardiovascular complication of immunotherapy and highlights to cardiologists the importance of aggressive treatments in patients with metastatic cancers whose prognosis has improved dramatically.
Identifiers		DOI: 10.1016/j.cjca.2017.09.025 PMID: 29275889
Full text		Article (Published version) (569 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Research groups		Groupe de recherche en hémodynamique (913) Immunothérapie des cancers (42)
Citation (ISO format)		FRIGERI, Mauro et al. Immune Checkpoint Inhibitor-Associated Myocarditis: A New Challenge for Cardiologists. In: Canadian Journal of Cardiology, 2018, vol. 34, n° 1, p. 92.e1-92.e3. doi: 10.1016/j.cjca.2017.09.025 https://archive-ouverte.unige.ch/unige:101415