Scientific article
Open access

Periaqueductal efferents to dopamine and GABA neurons of the VTA

Published inPloS one, vol. 13, no. 1, e0190297
  • The following information is missing from the Funding statement: Funding was provided by the European Research Council (ERC Advanced grant MeSSI).
  • DOI : 10.1371/journal.pone.0219476
  • PMID : 31269079
Publication date2018

Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we observed that PAG to VTA projection neurons are evenly distributed along the rostro-caudal axis of the PAG, but concentrated in its posterior and ventrolateral segments. Optogenetic projection targeting demonstrated that the PAG-to-VTA pathway is predominantly excitatory and targets similar proportions of Ih-expressing VTA DA and GABA neurons. Taken together, these results set the framework for functional analysis of the interplay between PAG and VTA in the regulation of reward and aversion.

  • Animals
  • Dopamine/metabolism
  • Female
  • GABAergic Neurons/metabolism
  • Male
  • Mice
  • Ventral Tegmental Area/metabolism/physiology
Noteinitially published as a preprint on bioRxiv: https://doi.org/10.1101/117416
Citation (ISO format)
NTAMATI RWAKA, Niels et al. Periaqueductal efferents to dopamine and GABA neurons of the VTA. In: PloS one, 2018, vol. 13, n° 1, p. e0190297. doi: 10.1371/journal.pone.0190297
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ISSN of the journal1932-6203

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