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Periaqueductal efferents to dopamine and GABA neurons of the VTA

Published in PloS one. 2018, vol. 13, no. 1, e0190297
Abstract Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organization of the VTA-projecting PAG neurons. Using rabies-based, cell type-specific retrograde tracing, we observed that PAG to VTA projection neurons are evenly distributed along the rostro-caudal axis of the PAG, but concentrated in its posterior and ventrolateral segments. Optogenetic projection targeting demonstrated that the PAG-to-VTA pathway is predominantly excitatory and targets similar proportions of Ih-expressing VTA DA and GABA neurons. Taken together, these results set the framework for functional analysis of the interplay between PAG and VTA in the regulation of reward and aversion.
Keywords AnimalsDopamine/metabolismFemaleGABAergic Neurons/metabolismMaleMiceVentral Tegmental Area/metabolism/physiology
PMID: 29304042
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Dataset: https://goo.gl/wabL6U
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
Swiss National Science Foundation: 310030_149985
Autre: Fondation Privée des Hopitaux Universitaires de Genève
European Commission: MESSI
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NTAMATI RWAKA, Niels et al. Periaqueductal efferents to dopamine and GABA neurons of the VTA. In: PloS one, 2018, vol. 13, n° 1, p. e0190297. doi: 10.1101/117416 https://archive-ouverte.unige.ch/unige:100745

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Deposited on : 2017-12-21

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