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Title

The ER phagosome connection in the era of membrane contact sites

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Published in Biochimica et Biophysica Acta. 2017, vol. 1864, no. 9, p. 1513-1524
Abstract Phagocytosis is an essential mechanism through which innate immune cells ingest foreign material that is either destroyed or used to generate and present antigens and initiate adaptive immune responses. While a role for the ER during phagosome biogenesis has been recognized, whether fusion with ER cisternae or vesicular derivatives occurs has been the source of much contention. Membrane contact sites (MCS) are tight appositions between ER membranes and various organelles that coordinate multiple functions including localized signalling, lipid transfer and trafficking. The discovery that MCS form between the ER and phagosomes now begs the question of whether MCS play a role in connecting the ER to phagosomes under different contexts. In this review, we consider the implications of MCS between the ER and phagosomes during cross-presentation and infection with intracellular pathogens. We also discuss the similarities between these contacts and those between the ER and plasma membrane and acidic organelles such as endosomes and lysosomes. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann.
Keywords AnimalsCalcium SignalingEndoplasmic Reticulum/metabolism/ultrastructureHumansMembrane FusionPhagosomes/metabolism/ultrastructure
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PMID: 28432021
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Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Signaux intracellulaires (210)
Project FNS: 31003A_149566
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NUNES-HASLER, Paula, DEMAUREX, Nicolas. The ER phagosome connection in the era of membrane contact sites. In: Biochimica et Biophysica Acta, 2017, vol. 1864, n° 9, p. 1513-1524. https://archive-ouverte.unige.ch/unige:100603

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Deposited on : 2017-12-20

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