Scientific article

Stressor-specific increase of vasopressin mRNA in paraventricular hypophysiotrophic neurons

Published inNeuroscience letters, vol. 170, no. 1, p. 35-38
Publication date1994

Cellular levels of vasopressin (VP) and corticotropin-releasing factor (CRF) RNA transcripts were determined in hypophysiotrophic neurons after open-field and immobilization stress using quantitative in situ hybridization. We found that 8 min open-field stress is sufficient to produce a significant up-regulation of CRF mRNA, without any concomitant changes in the level of VP mRNA. In contrast, 8 min immobilization stress resulted in an increased labeling density of both CRF and VP mRNAs. These results suggest that the level of CRF and VP transcripts in parvicellular hypophysiotrophic neurons is differentially regulated in a stressor-specific manner.

  • Animals
  • Autoradiography
  • Corticotropin-Releasing Hormone/ biosynthesis
  • Immobilization
  • In Situ Hybridization
  • Male
  • Neurons/ metabolism
  • Oligonucleotides/metabolism
  • Pituitary Gland, Posterior/cytology/ metabolism
  • RNA, Messenger/ biosynthesis
  • Rats
  • Rats, Inbred WKY
  • Stress, Psychological/ metabolism
  • Vasopressins/ biosynthesis
Citation (ISO format)
BARTANUSZ, V. et al. Stressor-specific increase of vasopressin mRNA in paraventricular hypophysiotrophic neurons. In: Neuroscience letters, 1994, vol. 170, n° 1, p. 35–38. doi: 10.1016/0304-3940(94)90232-1
ISSN of the journal0304-3940

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