Redox Control of Mitochondrial Calcium Uptake

Demaurex, Nicolas; Rosselin, Manon

doi:10.1016/j.molcel.2017.02.029

Scientific article

Editorial

English

Redox Control of Mitochondrial Calcium Uptake

ContributorsDemaurex, Nicolas

; Rosselin, Manon

Published inMolecular Cell, vol. 65, no. 6, p. 961-962

Publication date2017

Abstract

Dong et al. (2017) establish how the mitochondrial Ca2+ uniporter (MCU) integrates Ca2+ and oxidative stress signals by identifying a cysteine residue that controls MCU channel activity, a mechanism causing mitochondrial Ca2+ overload and cell death during oxidative stress.

Keywords

Calcium
Calcium Channels/chemistry
Mitochondria
Oxidation-Reduction
Oxidative Stress

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Research groups

Signaux intracellulaires (210)

Funding

Swiss National Science Foundation - Signaling at membrane contact sites between the endoplasmic reticulum, mitochondria, and phagosomes [149566]

Citation (ISO format)

DEMAUREX, Nicolas, ROSSELIN, Manon. Redox Control of Mitochondrial Calcium Uptake. In: Molecular Cell, 2017, vol. 65, n° 6, p. 961–962. doi: 10.1016/j.molcel.2017.02.029

Article (Published version)

Identifiers

PID : unige:100201
DOI : 10.1016/j.molcel.2017.02.029
PMID : 28306510

Journal ISSN1097-2765

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Update20/01/2025 09:10:20

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Redox Control of Mitochondrial Calcium Uptake

Dong et al. (2017) establish how the mitochondrial Ca2+ uniporter (MCU) integrates Ca2+ and oxidative stress signals by identifying a cysteine residue that controls MCU channel activity, a mechanism causing mitochondrial Ca2+ overload and cell death during oxidative stress.

Technical informations