Solvatochromic analysis of the retention mechanism of 2 novel stationary phases used for measuring lipophilicity by Rp-Hplc

Vallat, P.; Fan, W. Z.; el Tayar, Nabil; Carrupt, Pierre-Alain; Testa, Bernard

doi:10.1080/10826079208016330

Scientific article

English

Solvatochromic analysis of the retention mechanism of 2 novel stationary phases used for measuring lipophilicity by Rp-Hplc

ContributorsVallat, P.; Fan, W. Z.; el Tayar, Nabil; Carrupt, Pierre-Alain; Testa, Bernard

Published inJournal of liquid chromatography, vol. 15, no. 12, p. 2133-2151

Publication date1992

Abstract

The lipophilicity of a large set of solute was measured by reversed-phase high-performance liquid chromatography using two novel stationary phases, namely an octadecyl polyvinyl-alcohol copolymer (ODP) and an octyl-silane (OS) phase. Solvatochromic analysis of the results showed the ODP/buffer system to bear a close resemblance to 1-octanol/buffer system. In contrast, the OS phase is a stronger H-bond acceptor than 1-octanol and will lead to overestimating the lipophilicity of strong H-bond donor solutes

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Citation (ISO format)

VALLAT, P. et al. Solvatochromic analysis of the retention mechanism of 2 novel stationary phases used for measuring lipophilicity by Rp-Hplc. In: Journal of liquid chromatography, 1992, vol. 15, n° 12, p. 2133–2151. doi: 10.1080/10826079208016330

Identifiers

PID : unige:10000
DOI : 10.1080/10826079208016330

Journal ISSN0148-3919

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Solvatochromic analysis of the retention mechanism of 2 novel stationary phases used for measuring lipophilicity by Rp-Hplc

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