Impact of length of donor ICU stay on outcome of patients after pediatric liver transplantation with whole and in situ split liver grafts

Article Article scientifique Article Impact of length of donor ICU stay on outcome of patients after pediatric liver transplantation with whole and in situ split liver grafts eng 2021-11-05 2022-03 author Misar Aline 0000-0001-9948-0208 Pediatric Surgery Unit, Department of Pediatrics, Gynecology, and Obstetrics, Swiss Pediatric Liver Center, University Center of Pediatric Surgery of Western Switzerland, University of Geneva, Geneva, Switzerland. 960848 author Mclin Valérie Anne Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology, and Obstetrics, Swiss Pediatric Liver Center, University of Geneva, Geneva, Switzerland. 799651 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Calinescu-Tuleasca Ana Maria 0000-0002-3813-8991 Pediatric Surgery Unit, Department of Pediatrics, Gynecology, and Obstetrics, Swiss Pediatric Liver Center, University Center of Pediatric Surgery of Western Switzerland, University of Geneva, Geneva, Switzerland. 766852 author Wildhaber Barbara Pediatric Surgery Unit, Department of Pediatrics, Gynecology, and Obstetrics, Swiss Pediatric Liver Center, University Center of Pediatric Surgery of Western Switzerland, University of Geneva, Geneva, Switzerland. 595596 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) e14186 10.1111/petr.14186 34738698 1397-3142 https://onlinelibrary.wiley.com/doi/10.1111/petr.14186 Background: Patients who have a prolonged stay in the intensive care unit (ICU) are often excluded for organ donation because of supposed deleterious effects of a lengthy ICU stay. We aimed to determine the effects of a prolonged donor stay in the ICU on the outcome of liver transplantation (LT) in children. Methods: Retrospective review of 89 pediatric LT patients, age 0-18 years, period 2003-2018, including patients having undergone whole organ or in situ split LT. The patients were divided into two groups according to the donor length of stay in the ICU. A prolonged stay was defined as >5 days. Recipient, graft, and donor characteristics were compared; outcome parameters included recipient and graft survival rates and postoperative complications. Results: Group short (donor ICU stay <5 days) included 75 patients, group long (donor ICU stay >5 days) 14 patients. Baseline characteristics between recipients did not differ. Donors in group long had significantly more infectious complications and a higher gamma glutamyl transferase (gGT) the day of organ recovery. Incidence of biliary complications post-LT was significantly higher in group long (p = .029). Patient and graft survival rates did not differ significantly between groups. Conclusions: Donors with a prolonged stay in the ICU should still be considered for liver donation if they fulfill most other selection criteria. Recipients from donors having stayed in ICU >5 days may be at increased risk of biliary complications. ICU stay Biliary complications Donor Pediatric liver transplantation Adolescent Child Child, Preschool Female Graft Survival Humans Infant Intensive Care Units / statistics & numerical data Length of Stay / statistics & numerical data Liver Transplantation Male Postoperative Complications Retrospective Studies Tissue and Organ Procurement Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 559 Pathologies hépatiques congénitales et acquises de l'enfant 900 546 Recherche clinique en chirurgie pédiatrique 886 Pediatric transplantation 26 2 0fe8e9e5-a300-47e6-805d-e090b3148416 Article (Published version) Public Pediatric Transplantation - 2021 - .pdf 477248 application/pdf a28d35794b3d06dc8cd8677a0030871a8da19123d51260bca044147c8896ac69 601c73eb-5f87-4ed7-9b01-47fab03d21e0 Corrigendum Public Pediatric Transplantation - 2022 - .pdf 82277 application/pdf 628e9e25bf0ef22e6f457e82ea15c185d9774715622dd6ae4755abfec30baed0 Erreur dans le titre initial de l'article. 10.1111/petr.14349 35799314 openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Title	Published in	Year	Views	Downloads

Impact de la durée de séjour du donneur aux soins intensifs sur le résultat des transplantations hépatiques pédiatriques avec des greffes entières et divisées in situ		2023	148	65
Impact of length of donor ICU stay on outcome of patients after pediatric liver transplantation with whole and in situ split liver grafts	Pediatric transplantation	2022	90	338

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