Patterns of amyloid accumulation in amyloid-negative cases

Article Article scientifique Article Patterns of amyloid accumulation in amyloid-negative cases eng 2023-05-09 2023-09 author Alchera Nicola Istituto Nazionale di Fisica Nucleare (INFN), Genova, University of Genoa, Genoa, Italy. 948681 author Garibotto Valentina 0000-0003-2422-698X Division of Nuclear Medicine and Molecular Imaging, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland; Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, Switzerland; Center for Biomedical imaging (CIBM), Geneva, Switzerland. 704817 Département de radiologie et informatique médicale (RADIO) author Tomczyk Szymon Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland. 743605 author Treyer Valerie Department of Nuclear Medicine, University Hospital of Zurich, University of Zurich, Zurich, Switzerland; Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland. author Hocke Jean-Christophe Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland; Neurimmune, Schlieren, Switzerland. 44018 author Gietl Anton F Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland; Department for Geriatric Psychiatry, University Hospital for Psychiatry Zurich, Zurich, Switzerland. author Lövblad Karl-Olof Division of Radiology, Geneva University Hospitals, Geneva, Switzerland. 135154 Département de radiologie et informatique médicale (RADIO) author Scheffler Max 0000-0003-2274-5129 Division of Radiology, Geneva University Hospitals, Geneva, Switzerland. 686304 Département de radiologie et informatique médicale (RADIO) author Chincarini Andrea Istituto Nazionale di Fisica Nucleare (INFN), Genova, Genova, Italy. author Frisoni Giovanni Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland; Geneva Memory Center, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland. 810190 dept de réadaptation et gériatrie (MIGRG) author Ribaldi Federica Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland; Geneva Memory Center, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland. Electronic address: federica.ribaldi@unige.ch. 920118 dept de réadaptation et gériatrie (MIGRG) 99-108 10.1016/j.neurobiolaging.2023.05.006 37279618 0197-4580 https://www.sciencedirect.com/science/article/pii/S0197458023000994 Amyloid staging models showed that regional abnormality occurs before global positivity. Several studies assumed that the trajectory of amyloid spread is homogeneous, but clinical evidence suggests that it is highly heterogeneous. We tested whether different amyloid-β (Aβ) patterns exist by applying clustering on negative scans and investigating their demographics, clinical, cognitive, and biomarkers correlates, and cognitive trajectories. 151 individuals from Geneva and Zurich cohorts with T1-MRI, negative Aβ positron emission tomography (PET,centiloid<12) and clinical assessment were included. N=123 underwent tau PET, and N=65 follow-up neuropsychological assessment. We performed k-means clustering using 33 Aβ regional Standardized Uptake Vales ratio. Demographics, clinical, cognitive, and biomarkers differences were investigated. Longitudinal cognitive changes by baseline cluster status were estimated using a linear mixed model. The cluster analysis identified two clusters: temporal predominant (TP) and cingulate predominant (CP). TP tau deposition was higher than CP. A trend for a higher cognitive decline in TP compared to CP was observed. This study suggests the existence of two Aβ deposition patterns in the earliest phases of Aβ accumulation, differently prone to tau pathology and cognitive decline. Alzheimer's disease Amyloid-β Data-driven approach Positron emission tomography (PET) Humans Alzheimer Disease / pathology Amyloid beta-Peptides Amyloid Positron-Emission Tomography / methods Cognitive Dysfunction / diagnostic imaging Biomarkers Tau Proteins Dewey 616.0757 Dewey 618.97 Swiss National Science Foundation Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): correlation with clinical features and in vivo neuropathology 182772 CH Projects Swiss National Science Foundation The Biological Basis of Cognitive Impairment due to Suspected Non-Alzheimer’s Pathology (SNAP) : Studying the interplay between amyloidosis and tau-related neurodegeneration 169876 CH Projects Swiss National Science Foundation Individual cognitive risk profiling in aging according to Amyloid, Tau and Neurodegeneration imaging biomarkers 185028 CH Projects European Commission Common mechanisms and pathways in Stroke and Alzheimer's disease. 667375 CoSTREAM EU H2020 62 Département de radiologie et informatique médicale 227 65 Département de réadaptation et gériatrie 22B false 1222 Laboratoire de neuroimagerie et de traceurs moléculaires innovants 984 853 Troubles de mémoire et maladie d'Alzeimer 935 470 Ischémie cérébrale et connectivité 801 Neurobiology of aging 129 f30443e1-4268-492e-98cc-1fcb9276a8bd Article (Published version) Public 1-s2.0-S0197458023000994-main.pdf 3656635 application/pdf CC BY-4.0 92fc6412eae02c3b0f93869abedb1e942b68964e0c8d11a5669b3d3655de4fce 208ce0c8-1c5e-46c4-bdb9-264556d56a0a Supplemental data Public 1-s2.0-S0197458023000994-mmc1.docx 20176 application/vnd.openxmlformats-officedocument.wordprocessingml.document a92cacfa7f3e8986d6f4aec04da99dfeff1c49e3addd76f2e399f16fd1efa1b7 openAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

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Patterns of amyloid accumulation in amyloid-negative cases	Neurobiology of aging			2023	81	33

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Alchera, Nicola