Bioadhesive Hyaluronic Acid/Dopamine Hydrogels for Vascular Applications Prepared by Initiator-Free Crosslinking

Article Article scientifique Article Bioadhesive Hyaluronic Acid/Dopamine Hydrogels for Vascular Applications Prepared by Initiator-Free Crosslinking eng 2022-05-20 2022-05-20 author Melnik Tamara 882812 author Ben Ameur Senda 841152 author Kanfar Nasreddine 936488 author Vinet Laurent 698286 author Delie Salmon Florence 0000-0002-2637-5949 121330 author Jordan Olivier 0000-0003-3752-2198 133859 5706 10.3390/ijms23105706 35628516 1422-0067 https://www.mdpi.com/1422-0067/23/10/5706 <p>Intimal hyperplasia, a vascular pathology characterized by vessel wall thickening, is implicated in vein graft failures. For efficient prevention, a biodegradable drug delivery system should be applied externally to the graft for an extended time. Finding a gel suitable for such a system is challenging. We have synthesized HA-Dopamine conjugates (HA-Dop) with several degrees of substitution (DS) and used two crosslinking methods: initiator-free crosslinking by basic pH shift or commonly used crosslinking by a strong oxidizer, sodium periodate. The rheological properties, bioadhesion to vascular tissue, cytocompatibility with fibroblasts have been compared for both methods. Our results suggest that initiator-free crosslinking provides HA-Dop gels with more adequate properties with regards to vascular application than crosslinking by strong oxidizer. We have also established the cytocompatibility of the initiator-free crosslinked HA-Dop gels and the cytotoxicity of dopamine-sodium periodate combinations. Furthermore, we have incorporated a drug with anti-restenotic effect in perivascular application, atorvastatin, into the gel, which showed adequate release profile for intimal hyperplasia prevention. The oxidizer-free formulation with improved bioadhesion holds promise as an efficient and safe drug delivery system for vascular applications.</p> Atorvastatin Bioadhesion Hyaluronic acid Hydrogel Initiator-free crosslinking Mussel inspired polymers Perivascular administration Dewey 615 31 Section des sciences pharmaceutiques 17 false 883 Technologie pharmaceutique International journal of molecular sciences 23 10 9df306fb-f2e6-49a9-9774-f5732e9d9687 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 3581767 application/pdf CC BY openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Bioadhesive Hyaluronic Acid/Dopamine Hydrogels for Vascular Applications Prepared by Initiator-Free Crosslinking	International journal of molecular sciences			2022	244	324

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Kanfar, Nasreddine