Optimization of cardiac cine in the rat on a clinical 1.5-T MR system

Article Article scientifique Article Optimization of cardiac cine in the rat on a clinical 1.5-T MR system eng 2006-07-25 author Montet-Abou Karin 94106 author Daire Jean-Luc 650412 author Ivancevic Marko Kresimir 88112 author Hyacinthe Jean-Noël 629602 author Nguyen David 922809 author Jorge-Costa Manuel 23646 author Morel Denis 22755 author Vallée Jean-Paul 0000-0001-7546-2013 29185 Département de radiologie et informatique médicale (RADIO) 144-151 10.1007/s10334-006-0037-z 16865385 0968-5243 http://link.springer.com/10.1007/s10334-006-0037-z Object: the overall goal was to study cardiovascular function in small animals using a clinical 1.5-T MR scanner optimizing a fast gradient-echo cine sequence to obtain high spatial and temporal resolution. Materials and methods: normal rat hearts (n = 9) were imaged using a 1.5-T MR scanner with a spiral fast gradient-echo (fast field echo for Philips scanners) sequence, three Cartesian fast gradient-echo (turbo field echo for Philips scanners) sequences with different in-plane resolution, and with and without flow compensation and half-Fourier acquisition. The hearts of four rats were then excised and left-ventricle mass was weighed. Inter- and intra-observer variability analysis was performed for magnetic resonance imaging (MRI) measurements. Results: half-Fourier acquisition with flow compensation gave the best sequence in terms of image quality, spatial as well as temporal resolution, and suppression of flow artifact. Ejection fraction was 71 ± 4% with less than 5% inter- and intra-observer variability. A good correlation was found between MRI-calculated left-ventricular mass and wet weight. Conclusions: using optimized sequences on a clinical 1.5-T MR scanner can provide accurate quantification of cardiac function in small animals and can promote cardiovascular research on small animals at 1.5-T Algorithms Animals Heart Ventricles / anatomy & histology Image Enhancement / methods Image Interpretation, Computer-Assisted Magnetic Resonance Imaging / instrumentation Magnetic Resonance Imaging / methods Male Organ Size Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Stroke Volume / physiology Ventricular Function Ventricular Function, Left / physiology Video Recording / methods Dewey 616.0757 Dewey 617 62 Département de radiologie et informatique médicale 227 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 286 Imagerie cardiaque fonctionnelle 541 Magma 19 3 cbd5b6b8-2788-4862-a01c-7323f7203f74 Article (Published version) Restricted Article-scientifique-from-crossref.pdf 228269 application/pdf fb6f19ae23f73d8449620cd5be7f331169a182b4b82187624d35cc6dfa33d5b9 restrictedAccess Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Optimization of cardiac cine in the rat on a clinical 1.5-T MR system	Magma			2006	88	0

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Nguyen, David