Personality as a Predictor of Disability in Multiple Sclerosis

Article Article scientifique Article Personality as a Predictor of Disability in Multiple Sclerosis eng 2023-02-10 author Jacot De Alcantara Isabele Harumi 0000-0002-2033-6287 837619 Section de psychologie (PSICO) author Voruz Philippe 0000-0001-6796-8807 804968 Section de psychologie (PSICO) author Allali Gilles 507314 Département des neurosciences cliniques (OTONO) author Fragnoli Chloé 918120 author Antoniou Maria-Paraskevi 917331 author Lalive d'Epinay Patrice 636926 Département des neurosciences cliniques (OTONO) author Peron Julie Anne 705680 Section de psychologie (PSICO) acad010 10.1093/arclin/acad010 36764662 0887-6177 https://academic.oup.com/acn/advance-article/doi/10.1093/arclin/acad010/7034215 Objective: As personality changes and personality disorders are frequently observed in multiple sclerosis (MS), personality may be a prognostic factor for this disease. The present study investigated the influence of personality on disability, progression, and treatment adherence in MS. Method: Personality was assessed in 41 patients with Relapsing–Remitting MS (30 females; mean age = 42.63 years) using the NEO Personality Inventory—3rd edition. Disability was measured with the Expanded Disability Status Scale, and treatment adherence information was collected from the Swiss MS Cohort. Correlation, multiple linear and partial least square regressions were performed to examine relations between personality, disability, and treatment adherence in MS. Results: After accounting for age and time since disease onset, our analysis revealed that Neuroticism (β = 0.32, p = 0.01) and its Vulnerability facet (β = 0.28, p < 0.05) predicted greater disability, whereas Extraversion (β = −0.25, p = 0.04) and its Activity facet (β = −0.23, p < 0.05) predicted milder disability. Regarding disability progression, correlational analysis revealed that it was negatively correlated with Extraversion (r = −0.44, p = 0.02) and the Feelings facet of Openness (r = −0.41, p = 0.03), but regressions failed to highlight any predictive links. No significant results could be demonstrated for treatment adherence. Conclusions: Overall, our study showed that some personality traits can impact disability in MS, indicating that these should be considered in clinical practice, as they could be used to adapt and improve patients’ clinical support. Disability/handicaps Multiple sclerosis Personality and personality disorders Big Five Dewey 128.37 Dewey 616.8 Dewey 150 15 Centre interfacultaire en sciences affectives 0D8 61 Département des neurosciences cliniques 226 108 Section de psychologie 71 false 1409 Neuropsychologie clinique et expérimentale (CENLab) 505 Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale 843 Archives of clinical neuropsychology e78d944f-224d-433d-9ad9-dda943883f56 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 676559 application/pdf CC BY-NC-4.0 1aa0d6ea823a37b67b8657d98b43dafe53d190092333a98e0000f3b8a3a3a490 b4c72d42-4a62-4fab-b0df-06dfd14fda1f Supplemental data Public jacotdealcantara_et_al_supplementar.docx 289655 application/vnd.openxmlformats-officedocument.wordprocessingml.document 321eff07c093034f2f830c893721bb6249da150f6a0095f20a42d8d8d223cdd0 ba88fd60-8a63-4378-b93a-b497fa2949ba Supplemental data Public jacot_de_alcantara_et_al_sidata.xlsx 47810 application/vnd.openxmlformats-officedocument.spreadsheetml.sheet e1616233111a155915deb06bc2c7dad4bea827e86faaab30a26c56d0db5f19b8 openAccess Centres et instituts / Centre interfacultaire en sciences affectives Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de psychologie et des sciences de l'éducation / Section de psychologie

Title	Published in	Year	Views	Downloads

Personality as a Predictor of Disability in Multiple Sclerosis	Archives of clinical neuropsychology	2023	252	253
Coût cognitif du passage des représentations égocentrées à allocentrées		2021	284	344

Archive ouverte UNIGE

Fragnoli, Chloé