Evidence accumulation relates to perceptual consciousness and monitoring

Article Article scientifique Article Evidence accumulation relates to perceptual consciousness and monitoring eng 2021 author Pereira Sala Michaël 781750 author Megevand Pierre Bastien 0000-0002-0427-547X 510484 author Tan Mixue 916759 author Chang Wenwen author Wang Shuo author Rezai Ali author Seeck Margitta 133679 author Corniola Marco 0000-0003-4447-4585 583144 Marco Vincenzo Corniola author Momjian Shahan Marc 84022 author Bernasconi Fosco author Blanke Olaf 107390 author Faivre Nathan 3261 10.1038/s41467-021-23540-y 34059682 2041-1723 A fundamental scientific question concerns the neural basis of perceptual consciousness and perceptual monitoring resulting from the processing of sensory events. Although recent studies identified neurons reflecting stimulus visibility, their functional role remains unknown. Here, we show that perceptual consciousness and monitoring involve evidence accumulation. We recorded single-neuron activity in a participant with a microelectrode in the posterior parietal cortex, while they detected vibrotactile stimuli around detection threshold and provided confidence estimates. We find that detected stimuli elicited neuronal responses resembling evidence accumulation during decision-making, irrespective of motor confounds or task demands. We generalize these findings in healthy volunteers using electroencephalography. Behavioral and neural responses are reproduced with a computational model considering a stimulus as detected if accumulated evidence reaches a bound, and confidence as the distance between maximal evidence and that bound. We conclude that gradual changes in neuronal dynamics during evidence accumulation relates to perceptual consciousness and perceptual monitoring in humans. Adult Animals Consciousness/physiology Decision Making Drug Resistant Epilepsy/therapy Electrodes Implanted Electroencephalography Healthy Volunteers Humans Microelectrodes Neurons/physiology Parietal Lobe/cytology/physiology Perception/physiology Physical Stimulation/methods Single-Cell Analysis Young Adult Dewey 616.8 Swiss National Science Foundation The neuronal mechanisms underlying the perception of auditory and visual speech PZ00P3_167836 CH Careers Swiss National Science Foundation Using deep brain stimulation to dig out the subcortical correlates of consciousness P2ELP3_187974 CH Careers Swiss National Science Foundation 163398; 80365 CH 16 Centre interfacultaire de neurosciences 0D9 53 Département de neurosciences fondamentales 21A 61 Département des neurosciences cliniques 226 false 119 Epilepsie et Chirurgie 149 1361 Human Neuron Lab 1034 https://openneuro.org/datasets/ds001785/versions/1.1.1 Nature Communications 12 1 cc952e9d-bac4-44e9-88fb-6f7891d0b510 Article (Published version) Public s41467-021-23540-y.pdf 2371224 application/pdf CC BY 44cd628f-38ae-4687-bb3b-723f367d8591 Supplemental data Public 41467_2021_23540_MOESM1_ESM.pdf 1236232 application/pdf CC BY openAccess Centres et instituts / Centre interfacultaire de neurosciences Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Evidence accumulation relates to perceptual consciousness and monitoring	Nature Communications	2021	330	287

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