Can RNA-seq help in the diagnosis of diffuse large B-cell lymphoma?

Diplôme Master Can RNA-seq help in the diagnosis of diffuse large B-cell lymphoma? eng 2020 author Fonteneau Damien 879136 collaborator Lisacek Frédérique 0000-0002-0948-4537 639315 collaborator Christinat Yann director Mckee Thomas Alexander 549937 Amplification and sequencing of RNA are commonly used techniques to detect gene fusions, for the moment this technique is not used for lymphoma diagnosis as the classic oncogenes for this type of disease are not characterized by a gene fusion but by a gene swap, which does not alter the gene structure but their expression. In this study, I focus on Diffuse Large B Cell Lymphoma (DLBCL) as RNA quantificat This method allows me to show that different levels of expression can be detected with or without translocation for MYC, BCL2 and BCL6. An RNAseq using a panel capture might be useful for the characterization of DLBCL and maybe also for other tumors. Dewey 570 Bioinformatique et analyse des données en biologie 30 Section de biologie 16 false 8c098270-011b-4b79-ab70-ee2f3e96058f Master thesis Restricted Master_Thesis_Fonteneau_Damien.pdf 4245777 application/pdf restrictedAccess Faculté des sciences / Section de biologie

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Can RNA-seq help in the diagnosis of diffuse large B-cell lymphoma?				2020	73	2

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Fonteneau, Damien