Cell-free nucleic acids are present in blood products and regulate genes of innate immune response

Article Article scientifique Article Cell-free nucleic acids are present in blood products and regulate genes of innate immune response eng 2018 author Waldvogel Abramowski Sophie 87692 author Tirefort Diderik 134979 author Lau Pierre author Guichebaron Arthur author Taleb Sofiane 865375 author Modoux Christine author Lemoine Chaduc Coralie author Bruyere Cerdan Pascale author Roux-Lombard Pascale 22481 author Lecompte Thomas Pierre 768575 author Preynat-Seauve Olivier 561776 1671-1681 10.1111/trf.14613 29664127 0041-1132 Extracellular nucleic acids circulate in plasma. They are expected to be present in manufactured blood products eligible for transfusion, but little is known about their biological activity on human cells. The aim of this study is to investigate whether cell-free nucleic acids (CFNAs) are present and biologically active in red blood cell units (RBCUs), fresh frozen plasmas, and platelet concentrates. Dewey 616 56 Département de médecine 221 false 449 Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles 779 575 Groupe Lecompte Thomas Pierre (hématologie) 918 950 Génomique et métagénomique des produits sanguins labiles 956 Transfusion 58 7 775428a0-c5c0-4a35-896f-2d4435c877fa Article (Published version) Restricted Abramowski_et_al-2018-Transfusion.pdf 505665 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine

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Cell-free nucleic acids are present in blood products and regulate genes of innate immune response	Transfusion			2018	525	2

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Taleb, Sofiane