Harnessing Microglia and Macrophages for the Treatment of Glioblastoma

Article Article scientifique Revue de la littérature Harnessing Microglia and Macrophages for the Treatment of Glioblastoma eng 2019 author Prionisti Ioanna 864750 author Buehler Leo Hans 71923 author Walker Paul Richard 0000-0001-8999-6366 104900 author Jolivet Renaud 849014 10.3389/fphar.2019.00506 31231208 1663-9812 Glioblastoma multiforme (GBM) is the most malignant form of brain tumors, with a dismal prognosis. During the course of the disease, microglia and macrophages both infiltrate the tumor microenvironment and contribute considerably in glioma development. Thus, tumor-associated microglia and macrophages have recently emerged as potentially key therapeutic targets. Here, we review the physiology of microglia and their responses in brain cancer. We further discuss current treatment options for GBM using radiotherapy, and novel advances in our knowledge of microglia physiology, with emphasis on the recently discovered pathway that controls the baseline motility of microglia processes. We argue that the latter pathway is an interesting therapeutic avenue to pursue for the treatment of glioblastoma. Cancer Glioblastoma Macrophage Microglia Two-pore domain K+ channels Dewey 500.2 Dewey 616 Dewey 617 Autre SEFRI (REF-1131-52107) European Commission MEDICIS-produced radioisotope beams for medicine 642889 MEDICIS-PROMED EU H2020 34 Département de physique nucléaire et corpusculaire 132 56 Département de médecine 221 57 Département de chirurgie 222 false 270 Cultures cellulaires et transplantations 519 401 Immunobiologie des tumeurs du cerveau 669 562 Transplantation et hépatologie 905 Frontiers in Pharmacology 10 506 be11d2bb-e4b6-477c-a2ee-3062ca0f3177 Article (Published version) Public fphar-10-00506.pdf 1526294 application/pdf CC BY openAccess Faculté des sciences / Section de physique / Département de physique nucléaire et corpusculaire Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Harnessing Microglia and Macrophages for the Treatment of Glioblastoma	Frontiers in Pharmacology			2019	462	261

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Jolivet, Renaud