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Harnessing Microglia and Macrophages for the Treatment of Glioblastoma

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Published in Frontiers in Pharmacology. 2019, vol. 10, no. 506
Abstract Glioblastoma multiforme (GBM) is the most malignant form of brain tumors, with a dismal prognosis. During the course of the disease, microglia and macrophages both infiltrate the tumor microenvironment and contribute considerably in glioma development. Thus, tumor-associated microglia and macrophages have recently emerged as potentially key therapeutic targets. Here, we review the physiology of microglia and their responses in brain cancer. We further discuss current treatment options for GBM using radiotherapy, and novel advances in our knowledge of microglia physiology, with emphasis on the recently discovered pathway that controls the baseline motility of microglia processes. We argue that the latter pathway is an interesting therapeutic avenue to pursue for the treatment of glioblastoma.
Keywords CancerGlioblastomaMacrophageMicrogliaTwo-pore domain K+ channels
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PMID: 31231208
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Article (Published version) (1.5 MB) - public document Free access
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Research groups Cultures cellulaires et transplantations (519)
Transplantation et hépatologie (905)
Immunobiologie des tumeurs du cerveau (669)
Projects SEFRI (REF-1131-52107)
H2020: MEDICIS-PROMED
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PRIONISTI, Ioanna et al. Harnessing Microglia and Macrophages for the Treatment of Glioblastoma. In: Frontiers in Pharmacology, 2019, vol. 10, n° 506. doi: 10.3389/fphar.2019.00506 https://archive-ouverte.unige.ch/unige:127612

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Deposited on : 2019-12-09

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