UNIGE document Scientific Article - Review
previous document  unige:127612  next document
add to browser collection

Harnessing Microglia and Macrophages for the Treatment of Glioblastoma

Published in Frontiers in pharmacology. 2019, vol. 10, no. 506
Abstract Glioblastoma multiforme (GBM) is the most malignant form of brain tumors, with a dismal prognosis. During the course of the disease, microglia and macrophages both infiltrate the tumor microenvironment and contribute considerably in glioma development. Thus, tumor-associated microglia and macrophages have recently emerged as potentially key therapeutic targets. Here, we review the physiology of microglia and their responses in brain cancer. We further discuss current treatment options for GBM using radiotherapy, and novel advances in our knowledge of microglia physiology, with emphasis on the recently discovered pathway that controls the baseline motility of microglia processes. We argue that the latter pathway is an interesting therapeutic avenue to pursue for the treatment of glioblastoma.
Keywords CancerGlioblastomaMacrophageMicrogliaTwo-pore domain K+ channels
PMID: 31231208
Full text
Article (Published version) (1.5 MB) - public document Free access
Research groups Cultures cellulaires et transplantations (519)
Immunobiologie des tumeurs du cerveau (669)
Transplantation et hépatologie (905)
Autre: SEFRI (REF-1131-52107)
European Commission: MEDICIS-PROMED
(ISO format)
PRIONISTI, Ioanna et al. Harnessing Microglia and Macrophages for the Treatment of Glioblastoma. In: Frontiers in Pharmacology, 2019, vol. 10, n° 506. doi: 10.3389/fphar.2019.00506 https://archive-ouverte.unige.ch/unige:127612

277 hits



Deposited on : 2019-12-09

Export document
Format :
Citation style :