Expanding the knowledge of environmental sustainability in the biopharmaceutical industry: from manufacturing technologies to supply chain

Diplôme Thèse Expanding the knowledge of environmental sustainability in the biopharmaceutical industry: from manufacturing technologies to supply chain eng 2019-05-06 author Renteria Gamiz Ana 845892 director Patel Martin Kumar 810106 director Dewulf Jo 10.13097/archive-ouverte/unige:123699 urn:nbn:ch:unige-1236998 Sc. 5342 The biopharmaceutical industry is characterized by a rapidly growing market of its novel products, whose sustainability has hardly been evaluated. Only a small number of sustainability assessments have been published on this field, including a few Life Cycle Assessments (LCAs) which focused either on specific unit operations or on comparing particular equipments. In this PhD dissertation, the environmental sustainability of freeze drying as a key technology applied when manufacturing biopharmaceuticals is assessed. Two studies are presented evaluating (1) the resource efficiency of a typical batch freeze drying device and (2) the environmental sustainability of an industrial freeze drying process. In the second part, the environmental impact of selected biological medicines is assessed, focusing not only on their manufacturing processes but on the upstream and downstream supply chains associated to the products. Exergy and/or LCA methods are used as assessment tools. Hotspots are identified and measures for potential improvement are proposed. Thèse en cotutelle avec l'Université de Gand, Belgique Resource efficiency Life Cycle Assessment Exergy Biopharmaceuticals Dewey 550 Autre Swissuniversities 41 Département F.-A. Forel des sciences de l'environnement et de l'eau 153 false 935 Energy efficiency 1326ff89-b494-4f44-8fc7-0a2174762630 Thesis Public PhDthesis_AnaRenteria_UNIGE.pdf 4705444 application/pdf Restricted 2020-11-30 556233e221e4a682734dddf1971f1e5cf01d738a1fc9db178b51afd87d807a57 openAccess Faculté des sciences / Section des sciences de la Terre et de l'Environnement / Département F.-A. Forel des sciences de l'environnement et de l'eau

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Expanding the knowledge of environmental sustainability in the biopharmaceutical industry: from manufacturing technologies to supply chain				2019	752	410

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Renteria Gamiz, Ana