Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

Article Article scientifique Article Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex eng 2019 author Telley Ludovic 811749 author Agirman Gulistan 890976 author Prados Julien 0000-0002-8546-241X 561771 author Amberg N author Fievre Sabine 850352 author Oberst Polina 846753 author Bartolini Giorgia 844731 author Vitali Ilaria 733370 author Cadilhac Christelle 845270 author Hippenmeyer S author Nguyen L author Dayer Alexandre 84495 author Jabaudon Denis 0000-0003-2438-4769 682473 eaav2522 10.1126/science.aav2522 31073041 0036-8075 https://science.sciencemag.org/content/364/6440/eaav2522.long During corticogenesis, distinct subtypes of neurons are sequentially born from ventricular zone progenitors. How these cells are molecularly temporally patterned is poorly understood. We used single-cell RNA sequencing at high temporal resolution to trace the lineage of the molecular identities of successive generations of apical progenitors (APs) and their daughter neurons in mouse embryos. We identified a core set of evolutionarily conserved, temporally patterned genes that drive APs from internally driven to more exteroceptive states. We found that the Polycomb repressor complex 2 (PRC2) epigenetically regulates AP temporal progression. Embryonic age-dependent AP molecular states are transmitted to their progeny as successive ground states, onto which essentially conserved early postmitotic differentiation programs are applied, and are complemented by later-occurring environment-dependent signals. Thus, epigenetically regulated temporal molecular birthmarks present in progenitors act in their postmitotic progeny to seed adult neuronal diversity. Dewey 616.8 Dewey 616.89 53 Département de neurosciences fondamentales 21A 60 Département de psychiatrie 225 61 Département des neurosciences cliniques 226 false 535 Groupe Dayer Alexandre (Formation du circuit cortical) 875 540 Neurobiologie développementale et plasticité 880 0a6434c9-7972-44ea-8708-82e501660dc7 Biomedical Data Science Facility http://genebrowser.unige.ch/telagirdon/ Science 364 6440 4408f7ee-4ef7-432c-a9c1-8a1a2c8c0458 Article (Published version) Restricted eaav2522.full.pdf 3831462 application/pdf 9a42a081-901f-4deb-8b34-559b6d947004 Supplemental data Restricted aav2522_Telley_SM.pdf 18024871 application/pdf b91715e9-6472-4719-8cff-24db6d363523 Article (Accepted version) Public Telley_Combined_PDF.pdf.pdf 26536641 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Title	Published in	Year	Views	Downloads

Temporal plasticity of apical progenitors in the developing mouse neocortex	Nature	2019	665	5
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex	Science	2019	887	415

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