Scientific article
Open access

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

Published inScience, vol. 364, no. 6440, eaav2522
Publication date2019

During corticogenesis, distinct subtypes of neurons are sequentially born from ventricular zone progenitors. How these cells are molecularly temporally patterned is poorly understood. We used single-cell RNA sequencing at high temporal resolution to trace the lineage of the molecular identities of successive generations of apical progenitors (APs) and their daughter neurons in mouse embryos. We identified a core set of evolutionarily conserved, temporally patterned genes that drive APs from internally driven to more exteroceptive states. We found that the Polycomb repressor complex 2 (PRC2) epigenetically regulates AP temporal progression. Embryonic age-dependent AP molecular states are transmitted to their progeny as successive ground states, onto which essentially conserved early postmitotic differentiation programs are applied, and are complemented by later-occurring environment-dependent signals. Thus, epigenetically regulated temporal molecular birthmarks present in progenitors act in their postmitotic progeny to seed adult neuronal diversity.

Citation (ISO format)
TELLEY, Ludovic et al. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. In: Science, 2019, vol. 364, n° 6440, p. eaav2522. doi: 10.1126/science.aav2522
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ISSN of the journal0036-8075

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Creation11/04/2019 10:13:00 AM
First validation11/04/2019 10:13:00 AM
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