Dose Delivery and Image-Based Monitoring Strategies in TERA Linac Complexes for Hadron Therapy

Diplôme Thèse Dose Delivery and Image-Based Monitoring Strategies in TERA Linac Complexes for Hadron Therapy eng 2021-02-01 author Cuccagna Caterina 841523 director Iacobucci Giuseppe 752364 director Amaldi Ugo 10.13097/archive-ouverte/unige:149694 urn:nbn:ch:unige-1496942 Sc. 5541 Hadron therapy (HT) uses the physical and biological properties of charged particles to treat solid tumors. This thesis aims to contribute to two main HT research topics: the development of affordable beam accelerators complexes and of detector systems allowing the monitoring and control of the delivered dose. Two new linac accelerators for HT of the TERA Foundation are further studied, consolidating the bridge between the accelerators and medical physics worlds. The study includes the development of a 3D simulation software, FLUKA Monte Carlo-based, capable to track particles through the accelerator lines ending in the patient's body and fully predict HT beam characteristics. A new monitoring technique, called fast range verification, was developed and experimentally validated with the aim of verifying the Bragg Peak range for hadron treatments. It is based on Positron Emission Tomography and consists in β+ emitters detection from a short and low-dose pre-irradiation of a tumor part. Hadron therapy Proton therapy Particle therapy Positron Emission Tomography FLUKA CNAO CERN Medical physics Dewey 500.2 34 Département de physique nucléaire et corpusculaire 132 false e2f25db7-d0fd-486b-a838-35e3f3357987 Thesis Public These_Cuccagna.pdf 24919656 application/pdf openAccess Faculté des sciences / Section de physique / Département de physique nucléaire et corpusculaire

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Dose Delivery and Image-Based Monitoring Strategies in TERA Linac Complexes for Hadron Therapy				2021	715	782

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Cuccagna, Caterina