The role of anaerobes in diabetic foot infections

Article Article scientifique Revue de la littérature The role of anaerobes in diabetic foot infections eng 2015 author Charles Patrick 822949 author Uckay Ilker 134868 author Kressmann Benjamin author Emonet Stéphane 0000-0002-1201-742X 89139 Stéphane Paul Emonet author Lipsky Benjamin Alan 793658 8-13 10.1016/j.anaerobe.2015.03.009 25841893 1075-9964 Diabetic foot infections (DFI) are a common cause of morbidity and, on occasion, even mortality. Infection can be either mono- or polymicrobial, with a wide variety of potential pathogens. Anaerobes may be involved, particularly in wounds that are deeper or more chronic, and are more frequently identified when using modern molecular techniques, such as 16s PCR and pyrosequencing. It remains unclear whether the presence of anaerobes in DFI leads to more severe manifestations, or if these organisms are largely colonizers associated with the presence of greater degrees of tissue ischemia and necrosis. Commonly used empiric antibiotic therapy for diabetic foot infections is generally broad-spectrum and usually has activity against the most frequently identified anaerobes, such as Peptostreptococcus and Bacteroides species. Adequate surgical debridement and, when needed, foot revascularization may be at least as important as the choice of antibiotic to achieve a successful treatment outcome. Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 74 Chirurgie orthopédique et traumatologique 98 Anaerobe 34 b62c2d05-dfe8-4272-a18b-355871dc07f0 Article (Published version) Restricted 1-s2.0-S1075996415300019-main.pdf 313325 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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The role of anaerobes in diabetic foot infections	Anaerobe			2015	596	1

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Charles, Patrick