Evaluation of the antioxidant activity profile of newly synthesized flavonoids

Diplôme Master Evaluation of the antioxidant activity profile of newly synthesized flavonoids eng 2014 author Malandra Veronica 810469 director Carrupt Pierre-Alain 135654 Oxidative stress has proved to be involved in a panel of diseases, including neurodegenerative and cardiovascular diseases and cancer. In the case of neurodegenerative diseases, their multifactorial origin has promoted the research for molecules with multiple biological activities, capable of combining for instance neuroprotective and antioxidant properties, as well as the ability to penetrate into the central nervous system. In this context, and as part of a continuing collaboration with organic chemists, this work aims to analyse the antioxidant activity of newly synthetized flavonoids derivatives in order to rationalize the correlation between the electronic and molecular structure of flavonoids with its scavenging activity. The 49-set of flavonoid synthetic derivatives selected for this study includes 20 chalcones (Figures 1 and 2) and 29 aurones (Figures 3 and 4). Dewey 615 Travail personnel de recherche, Master en Pharmacie 31 Section des sciences pharmaceutiques 17 false 885 Pharmacochimie d68ad066-620c-4626-a819-41cbcec19215 Master thesis Restricted TPR-UNIGE__[veronica.malandra-13.06.2014-13h20].pdf 2021000 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Evaluation of the antioxidant activity profile of newly synthesized flavonoids				2014	318	2

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Malandra, Veronica