Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome

Article Article scientifique Article Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome eng 2021-12-15 author Ilen Laura 934454 author Feller Clémence 847302 author Eliez Stéphan 39336 author Micol Eva 806559 author Delavari Farnaz 930325 author Sandi Carmen author Zanoletti Olivia author Schneider Maude 594384 100103 10.1016/j.cpnec.2021.100103 2666-4976 https://www.sciencedirect.com/science/article/pii/S2666497621000771 Background 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to alterations in hypothalamic-pituitary-adrenocortical (HPA)-axis functioning. In the current study, we investigated for the first time diurnal salivary cortisol profiles in adolescents and young adults with 22q11DS as well as their link with stress exposure, coping strategies and psychopathology, including psychotic symptoms. Methods Salivary cortisol was collected from adolescents and young adults with 22q11DS (n = 30, age = 19.7) and matched healthy controls (HC; n = 36, age = 18.5) six times a day for two days. Exposure to stressful life events, including peer victimization, coping strategies and general psychopathology were assessed with questionnaires. Psychotic symptoms and psychiatric comorbidities were evaluated with clinical interviews. Results We observed similar daily levels and diurnal profiles of salivary cortisol in adolescents and young adults with 22q11DS compared to HCs. However, participants with 22q11DS reported less frequent exposure to stress than HCs. In 22q11DS, we observed a significant association between the use of non-adaptive coping strategies and the severity of psychotics symptoms. Cortisol level was not associated to severity of psychotic symptoms, but elevated cortisol awakening response (CAR) was found in participants with 22q11DS with higher levels of general psychopathology. Conclusions Our results do not support earlier propositions of altered HPA-axis functioning in 22q11DS but highlight the need to further investigate diurnal cortisol as an indicator of HPA-axis functioning and its link with (earlier) stress exposure and psychopathology in this population. Interventions should target the development of adaptive coping skills in preventing psychosis in 22q11DS. Diurnal cortisol HPA-axis Stress exposure Coping strategies Psychopathology Psychosis Dewey 150 Dewey 576.5 Dewey 616.89 Swiss National Science Foundation Towards an embodied and ecological understanding of social impairments in neurodevelopmental disorders PZ00P1_174206 CH Careers Swiss National Science Foundation NCCR 'SYNAPSY - The synaptic bases of mental diseases' (phase III) CH Programmes Swiss National Science Foundation Swiss VCFS Cohort: a 10-year longitudinal investigation from genes to brain to cognition for understanding psychosis proneness in 22q11.2 deletion 324730_144260 CH Project funding 135 Département de médecine génétique et développement 21D 60 Département de psychiatrie 225 108 Section de psychologie 71 false 421 Laboratoire d'imagerie et de psychopathologie développementale 693 1302 Unité de psychologie clinique des situations de handicap https://doi.org/10.26037/yareta:cudwhbeqmnhalolobz2q4eo2di Comprehensive psychoneuroendocrinology 9 f7ed65a0-ceb5-49cc-bc7f-941f1942cc2a Article (Published version) Public 1-s2.0-S2666497621000771-main.pdf 1395858 application/pdf CC BY-NC-ND openAccess Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de psychologie et des sciences de l'éducation / Section de psychologie

Title	Published in	Year	Views	Downloads

Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome	Comprehensive psychoneuroendocrinology	2021	382	296
Comparaisons de normes pour le Rorschach en Système Intégré pour des enfants de 7 à 10 ans		2018	258	7

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