Synthesis of 11ß-hydroxysteroid dehydrogenase type 1 inhibitors and their corresponding PROTAC to be studied in immunotherapy of renal cell cancer (RCC)

Diplôme Master Synthesis of 11ß-hydroxysteroid dehydrogenase type 1 inhibitors and their corresponding PROTAC to be studied in immunotherapy of renal cell cancer (RCC) eng 2020 author Dalouadi Meryem 798892 director Scapozza Leonardo 600318 The role of cortisol in different endocrine related diseases is quite established, which lead to the development of various selective 11ß-HSD1 inhibitors. To date, none of them has made it through clinical trials, mainly because of a lack of efficacy in the targeted disease. Recently, the intracrine role of cortisol in immune cells began to be investigated, opening a pathway for repurposing those drug candidates. The following work presents the synthesis of 11ß-HSD1 inhibitors and the development of their corresponding PROTAC. The compounds were selected among a list of different documented inhibitors to be engaged in a project whose aim is to provide a proof of concept that would demonstrate the role of 11ß-HSD1 in the immune system response to cancer. Dewey 615 Master en pharmacie 31 Section des sciences pharmaceutiques 17 false 880 Biochimie pharmaceutique d1cb50b9-3aee-434d-a42c-75372c2229af Master thesis Restricted 200708165755_dalouad0__TPR.pdf 9841844 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Synthesis of 11ß-hydroxysteroid dehydrogenase type 1 inhibitors and their corresponding PROTAC to be studied in immunotherapy of renal cell cancer (RCC)				2020	79	3

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Dalouadi, Meryem

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