The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention

Article Article scientifique Article The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention eng 2013 author Topf Florian 788846 author Schvartz Domitille 665782 author Gaudet Pascale 739115 author Priego-Capote F. author Zufferey Bakos Anne 527383 author Turck Natacha 632628 author Binz Pierre-Alain 122663 author Fontana Pierre 135328 author Wiederkehr Andreas 630329 author Finamore Francesco 764189 author Xenarios Ioannis 767135 author Goodlett D. author Kussmann M. author Bergsten P. author Sanchez Jean-Charles 0000-0002-8733-5932 24399 3-11 10.1016/j.trprot.2013.03.002 2212-9626 http://www.sciencedirect.com/science/article/pii/S221296341300003X Type 2 diabetes is a worldwide disease reaching epidemic dimensions. The rapid progressionof the disease urgently calls for both a broader and deeper understanding of its pathophysi-ology. In line with this statement, the Human Diabetes Proteome Project (HDPP) was officiallylaunched at the 11th HUPO meeting in Boston, 2012. A special session was dedicated to thisnew initiative, gathering experts in the main topics related to diabetes and its associatedcomplications. Key issues were debated with a focus on how deranged circulating glucoseand free fatty acids induce dysfunction. It has been decided that HDPP will therefore focus onstudying the early stages of diabetes that lead to abnormal glucose and lipid levels. The ini-tiative will initially focused on islets of Langerhans, insulin-producing cell lines, and bloodhuman samples from diabetes-related cohorts. In subsequent stages HDPP will investigatetarget tissues in which glucose and lipids could promote protein dysfunctions. Omics-rootedsystems approaches enhanced by bioinformatics will be deployed to unravel effects of lipidsand glucose triggering diabetes initiation and progression. A first milestone has been defined Dewey 576 Dewey 616 136 Département de biologie structurale et bioinformatique 21E 56 Département de médecine 221 false 11 Plaquettes et antithrombotiques 13 369 Biomarqueurs 635 Translational proteomics 1 1 38d13a9d-f8ff-456c-a7f5-afacecc4007b Article (Published version) Public 101016 j.trprot.2013.03.002.pdf 727855 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique Faculté de médecine / Section de médecine clinique / Département de médecine

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The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention	Translational proteomics			2013	721	323

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