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The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention

Published inTranslational proteomics, vol. 1, no. 1, p. 3-11
Publication date2013
Abstract

Type 2 diabetes is a worldwide disease reaching epidemic dimensions. The rapid progressionof the disease urgently calls for both a broader and deeper understanding of its pathophysi-ology. In line with this statement, the Human Diabetes Proteome Project (HDPP) was officiallylaunched at the 11th HUPO meeting in Boston, 2012. A special session was dedicated to thisnew initiative, gathering experts in the main topics related to diabetes and its associatedcomplications. Key issues were debated with a focus on how deranged circulating glucoseand free fatty acids induce dysfunction. It has been decided that HDPP will therefore focus onstudying the early stages of diabetes that lead to abnormal glucose and lipid levels. The ini-tiative will initially focused on islets of Langerhans, insulin-producing cell lines, and bloodhuman samples from diabetes-related cohorts. In subsequent stages HDPP will investigatetarget tissues in which glucose and lipids could promote protein dysfunctions. Omics-rootedsystems approaches enhanced by bioinformatics will be deployed to unravel effects of lipidsand glucose triggering diabetes initiation and progression. A first milestone has been defined

Citation (ISO format)
TOPF, Florian et al. The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention. In: Translational proteomics, 2013, vol. 1, n° 1, p. 3–11. doi: 10.1016/j.trprot.2013.03.002
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ISSN of the journal2212-9626
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Creation05/17/2013 10:48:00 AM
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Update time03/14/2023 8:11:18 PM
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