Next-Generation Sequencing Techniques to Diagnose Culture-Negative Subacute Native Aortic Endocarditis

Article Article scientifique Rapport de cas Next-Generation Sequencing Techniques to Diagnose Culture-Negative Subacute Native Aortic Endocarditis eng 2025-07 author Vetterli Delphine 752581 author Zennaro Morgana 931275 author Tacchini Virginie 781177 author Lobrinus Johannes Alexander 647649 author Prendki Virginie 0000-0003-1315-2938 811987 dept de réadaptation et gériatrie (MIGRG) author Lazarevic Vladimir 0000-0002-6839-2536 684594 Département de médecine (DEMED) author Schrenzel Jacques 29184 Département de médecine (DEMED) 1478-1481 10.3201/eid3107.241739 40562730 1080-6040 PMC12205438 https://wwwnc.cdc.gov/eid/article/31/7/24-1739_article Next-generation sequencing might improve diagnosis of infective endocarditis. A case in Switzerland was initially attributed to Solobacterium moorei bacteria. Metagenomic analysis of the affected heart valve detected Streptococcus gordonii, but not S. moorei, illustrating that the results of molecular detection can vary depending on sampling time and anatomic site. DNA Switzerland Bacteremia Bacteria Cell-free nucleic acid Endocarditis Infective endocarditis McfDNA Sequence analysis Streptococci Humans Male Aortic Valve / microbiology Endocarditis / diagnosis Endocarditis / microbiology Endocarditis, Bacterial / diagnosis Endocarditis, Bacterial / microbiology High-Throughput Nucleotide Sequencing / methods Streptococcus gordonii / genetics Streptococcus gordonii / isolation & purification Aged, 80 and over Dewey 616.07 Dewey 616 Dewey 590 Dewey 618.97 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 65 Département de réadaptation et gériatrie 22B 23 Institut de génétique et de génomique 0DH false 1440 Infections de la personne âgée 1062 338 Génomique et microbiote 604 Emerging infectious diseases 31 7 8f86cb56-eb3c-4d35-9c76-fb00f49a87a7 Article (Published version) Public Article_scientifique_from_europePmc.pdf 812414 application/pdf 40c8d26cf88c0beb26be4c8480bff0ae83303e354731bca5e88c7d17e5b57dc8 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie Centres et instituts / Institut de génétique et de génomique

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Next-Generation Sequencing Techniques to Diagnose Culture-Negative Subacute Native Aortic Endocarditis	Emerging infectious diseases			2025	25	198

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Vetterli, Delphine