A nap to recap or how reward regulates hippocampal-prefrontal memory networks during daytime sleep in humans

Article Article scientifique Article A nap to recap or how reward regulates hippocampal-prefrontal memory networks during daytime sleep in humans eng 2015 author Igloi Kinga Katinka 731860 author Gaggioni Giulia 730232 author Sterpenich Virginie 0000-0002-2125-833X 685195 author Schwartz Sophie 0000-0001-7718-4053 35633 10.7554/eLife.07903 26473618 2050-084X Sleep plays a crucial role in the consolidation of newly acquired memories. Yet, how our brain selects the noteworthy information that will be consolidated during sleep remains largely unknown. Here we show that post-learning sleep favors the selectivity of long-term consolidation: when tested three months after initial encoding, the most important (i.e., rewarded, strongly encoded) memories are better retained, and also remembered with higher subjective confidence. Our brain imaging data reveals that the functional interplay between dopaminergic reward regions, the prefrontal cortex and the hippocampus contributes to the integration of rewarded associative memories. We further show that sleep spindles strengthen memory representations based on reward values, suggesting a privileged replay of information yielding positive outcomes. These findings demonstrate that post-learning sleep determines the neural fate of motivationally-relevant memories and promotes a value-based stratification of long-term memory stores. Human Neuroscience Memory Hippocampus Dewey 128.37 Dewey 616.8 Axa Foundation Swiss National Science Foundation Emotional relevance and sleep shape neural plasticity: A multimodal neuroimaging investigation in humans 135653 CH Project funding Swiss National Science Foundation NCCR Affective Sciences: Emotion in Individual Behavior and Social Processes (phase I) CH Programmes 15 Centre interfacultaire en sciences affectives 0D8 53 Département de neurosciences fondamentales 21A false 1241 Affective sciences 495 Neuroimagerie du Sommeil et de la Cognition 832 eLife 4 08780483-0c9d-4f52-8674-2504994815bd Article (Published version) Public eLife.07903.full.pdf 4628438 application/pdf openAccess Centres et instituts / Centre interfacultaire en sciences affectives Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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A nap to recap or how reward regulates hippocampal-prefrontal memory networks during daytime sleep in humans	eLife			2015	695	318

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Gaggioni, Giulia