Mapping interictal epileptic discharges using mutual information between concurrent EEG and fMRI

Article Article scientifique Article Mapping interictal epileptic discharges using mutual information between concurrent EEG and fMRI eng 2013 author Caballero Gaudes Cesar 718717 author Van De Ville Dimitri 0000-0002-2879-3861 638484 author Grouiller Frédéric 0000-0003-3445-5831 684576 author Thornton Rachel author Lemieux Louis author Seeck Margitta 133679 author Lazeyras François 512748 author Vulliemoz Serge 0000-0002-1877-8625 712268 248-262 10.1016/j.neuroimage.2012.12.011 23247187 1053-8119 The mapping of haemodynamic changes related to interictal epileptic discharges (IED) in simultaneous electroencephalography (EEG) and functional MRI (fMRI) studies is usually carried out by means of EEG-correlated fMRI analyses where the EEG information specifies the model to test on the fMRI signal. The sensitivity and specificity critically depend on the accuracy of EEG detection and the validity of the haemodynamic model. In this study we investigated whether an information theoretic analysis based on the mutual information (MI) between the presence of epileptic activity on EEG and the fMRI data can provide further insights into the haemodynamic changes related to interictal epileptic activity. The important features of MI are that: 1) both recording modalities are treated symmetrically; 2) no requirement for a-priori models for the haemodynamic response function, or assumption of a linear relationship between the spiking activity and BOLD responses, and 3) no parametric model for the type of noise or its probability distribution is necessary for the computation of MI. Adolescent Adult Brain/physiopathology Brain Mapping/methods Child Electroencephalography/methods Epilepsy/physiopathology Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging/methods Male Middle Aged Models, Theoretical Signal Processing, Computer-Assisted Young Adult Dewey 616.0757 Dewey 616.8 61 Département des neurosciences cliniques 226 62 Département de radiologie et informatique médicale 227 false 119 Epilepsie et Chirurgie 149 1279 Epilepsie et réseaux cérébraux 1002 284 Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) 539 552 Traitement d'images médicales 893 NeuroImage 68 41390569-ca9a-4f11-9546-ea80405ee8af Article (Published version) Restricted 1-s2.0-S1053811912011883-main.pdf 2655686 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Title	Published in	Year	Views	Downloads

Total activation: fMRI deconvolution through spatio-temporal regularization	NeuroImage	2013	724	618
Spatial mapping of interictal epileptic discharges in fMRI with total activation	Proceedings	2013	630	0
Mapping interictal epileptic discharges using mutual information between concurrent EEG and fMRI	NeuroImage	2013	716	2

Archive ouverte UNIGE

Caballero Gaudes, Cesar