A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder

Article Article scientifique Rapport de cas A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder eng 2019 author Galova Andréa 703709 author Berney Patricia Elisabeth 99933 author Desmeules Jules Alexandre 73542 author Sergentanis Ioannis 927604 author Besson Marie 87576 1-5 10.1186/s12888-019-2055-1 30782143 1471-244X Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; however, these reports described cholinergic rebound following cessation of high doses of clozapine in patients diagnosed with schizophrenia. Here, we report a case of rebound cholinergic syndrome and catatonia in a male patient three days after abrupt discontinuation of 50 mg of clozapine prescribed for type I bipolar affective disorder. Withdrawal syndromes Cholinergic rebound syndrome Low dose clozapine Bipolar affective disorder Pharmacodynamic properties Overlapping switch strategies Case report Dewey 616.89 Dewey 617 60 Département de psychiatrie 225 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 302 Groupe Desmeules Jules (pharmacologie/toxicologie) 567 BMC Psychiatry 19 73 f2407647-5e9d-4a4a-9488-8c50d0a1ac2a Article (Published version) Public 12888_2019_Article_2055.pdf 549102 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder	BMC Psychiatry			2019	443	468

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Galova, Andréa