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Scientific article
Case report
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A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder

Published inBMC Psychiatry, vol. 19, no. 73, p. 1-5
Publication date2019
Abstract

Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; however, these reports described cholinergic rebound following cessation of high doses of clozapine in patients diagnosed with schizophrenia. Here, we report a case of rebound cholinergic syndrome and catatonia in a male patient three days after abrupt discontinuation of 50 mg of clozapine prescribed for type I bipolar affective disorder.

Keywords
  • Withdrawal syndromes
  • Cholinergic rebound syndrome
  • Low dose clozapine
  • Bipolar affective disorder
  • Pharmacodynamic properties
  • Overlapping switch strategies
  • Case report
Citation (ISO format)
GALOVA, Andréa et al. A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder. In: BMC Psychiatry, 2019, vol. 19, n° 73, p. 1–5. doi: 10.1186/s12888-019-2055-1
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ISSN of the journal1471-244X
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Creation05/24/2019 4:17:00 PM
First validation05/24/2019 4:17:00 PM
Update time03/15/2023 5:11:49 PM
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