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A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder |
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Published in | BMC psychiatry. 2019, vol. 19, no. 73, p. 1-5 | |
Abstract | Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; however, these reports described cholinergic rebound following cessation of high doses of clozapine in patients diagnosed with schizophrenia. Here, we report a case of rebound cholinergic syndrome and catatonia in a male patient three days after abrupt discontinuation of 50 mg of clozapine prescribed for type I bipolar affective disorder. | |
Keywords | Withdrawal syndromes — Cholinergic rebound syndrome — Low dose clozapine — Bipolar affective disorder — Pharmacodynamic properties — Overlapping switch strategies — Case report | |
Identifiers | PMID: 30782143 | |
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Research group | Groupe Desmeules Jules (pharmacologie/toxicologie) (567) | |
Citation (ISO format) | GALOVA, Andréa et al. A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder. In: BMC Psychiatry, 2019, vol. 19, n° 73, p. 1-5. doi: 10.1186/s12888-019-2055-1 https://archive-ouverte.unige.ch/unige:118580 |