High density electric source imaging in childhood-onset epilepsy due to focal cortical dysplasia

Article Article scientifique Article High density electric source imaging in childhood-onset epilepsy due to focal cortical dysplasia eng 2022-07-26 2022 author Wanders Aurélie Neuropediatric Unit, Department of the Woman, Child and Adolescent, Geneva University Hospitals, Geneva, Switzerland. 700589 author Garibotto Valentina 0000-0003-2422-698X Department of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland. 704817 Département de radiologie et informatique médicale (RADIO) author Spinelli Laurent EEG and Epilepsy Unit, Department of Neurology, Geneva University Hospitals, Geneva, Switzerland. 105795 author Beniczky Sándor Danish Epilepsy Centre, Dianalund, Denmark and Aarhus University, Aarhus, Denmark. author Vulliemoz Serge 0000-0002-1877-8625 EEG and Epilepsy Unit, Department of Neurology, Geneva University Hospitals, Geneva, Switzerland. 712268 Département des neurosciences cliniques (OTONO) author Daniel Roy Thomas Department of Neurosurgery, Lausanne University Hospitals, Lausanne, Switzerland. author Schaller Karl Lothard Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland.,Faculty of Medicine, University of Geneva, Geneva, Switzerland. 658606 Département des neurosciences cliniques (OTONO) author Bartoli Andréa Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland. 840772 author Korff Christian 0000-0002-3328-7680 Neuropediatric Unit, Department of the Woman, Child and Adolescent, Geneva University Hospitals, Geneva, Switzerland. 30053 Département de Pédiatrie, Gynécologie et Obstétrique (PETRI) author Seeck Margitta EEG and Epilepsy Unit, Department of Neurology, Geneva University Hospitals, Geneva, Switzerland. 133679 Département des neurosciences cliniques (OTONO) 245-251 10.1016/j.cnp.2022.07.002 36062078 2467-981X PMC9428727 https://www.sciencedirect.com/science/article/pii/S2467981X22000282 Objective: The goal of this study was to investigate the diagnostic utility of electric source imaging (ESI) in the presurgical evaluation of children with focal cortical dysplasia (FCD) and to compare it with other imaging techniques. Methods: Twenty patients with epilepsy onset before 18 years, surgically treated focal epilepsy with a minimal follow-up of 2 years, and histologically proven FCD were retrospectively selected. All patients underwent MRI, positron emission tomography (PET), and 16 patients also had ictal single-photon emission computed tomography (iSPECT). ESI, using EEG with 64 electrodes or more (HD-ESI), was performed in all 20 patients. We determined sensitivity, specificity and accuracy of ESI, and compared its yield to that of other imaging techniques. Results: Twelve patients were seizure-free post-operatively (60%). Among all patients, highest localization accuracy (80%) was obtained with ESI, followed by PET and iSPECT (75%). When results from ESI and SPECT were concordant 100% of patients achieved Engel I outcome. If ESI and PET showed concordant localization, 90% of patients achieved postoperative seizure freedom. Conclusions: Our findings demonstrate that HD-ESI allows accurate localization of the epileptogenic zone in patients with FCD. Significance: In combination with other imaging modalities, ESI helps with planning a more accurate surgery and therefore, the chances of postoperative seizure control are higher. Since it is based on EEG recordings, it does not require sedation, which is particularly interesting in pediatric patients. ESI represents an important imaging tool in focal epilepsies due to cortical dysplasia, which might be difficult to detect on standard imaging. Children Electric source imaging Epilepsy surgery Focal cortical dysplasia Outcome Dewey 616.8 Dewey 616.0757 Dewey 617 Dewey 618 Swiss National Science Foundation Transcranial electrical current stimulation as a treatment in epilepsy 163398 CH Projects Swiss National Science Foundation Predict and Monitor Epilepsy After a First Seizure: The Swiss-First Study 180365 CH Programmes Swiss National Science Foundation Network Diagnosis for Epilepsy 192749 CH Projects Swiss National Science Foundation Exploring brain communication pathways by combining diffusion based quantitative structural connectivity and EEG source imaging : application to physiological and epileptic networks 170873 CH Programmes 16 Centre interfacultaire de neurosciences 0D9 62 Département de radiologie et informatique médicale 227 58 Département de pédiatrie, gynécologie et obstétrique 223 61 Département des neurosciences cliniques 226 57 Département de chirurgie 222 false 1222 Laboratoire de neuroimagerie et de traceurs moléculaires innovants 984 1279 Epilepsie et réseaux cérébraux 1002 119 Epilepsie et Chirurgie 149 513 Groupe Schaller Karl Lothard (neurochirurgie) 851 Clinical neurophysiology practice 7 05f599a5-08af-427d-9668-e7e1ee54dd6a Article (Published version) Public Article-scientifique-from-europePmc.pdf 992663 application/pdf CC BY-NC-ND-4.0 2d07e6971d0643927552e42e5d5240e8cfedec2d22a2b1958180ebdb6c1f7f6e openAccess Centres et instituts / Centre interfacultaire de neurosciences Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Wanders, Aurélie